Comprehensive Analysis of AR Alterations in Circulating Tumor DNA from Patients with Advanced Prostate Cancer.

Somatic alterations in circulating tumor DNA (ctDNA) is also associated to remedy response or prognosis in prostate most cancers (PCa). The purpose was to characterize androgen receptor gene (AR) amplifications and mutations detected in ctDNA from victims with PCa and to extra understand the somatic genetic heterogeneity of superior prostate most cancers.

This study included a heterogeneous group of 892 victims with superior PCa (predominantly castrate-resistant prostate most cancers) with AR alterations detected in ctDNA that underwent next-generation sequencing of 54 to 73 genes by the use of Guardant360 testing (Guardant Health, Inc., Redwood City, CA).

Distribution and summary of AR alterations detected, the affiliation of AR alterations with completely different genes, and a pathway analysis are reported.The median absolute plasma copy number of AR amplifications was 3.3 (range, 1.2-165.2).

Many victims had a variety of AR mutations; a whole of 112 distinctive mutations have been acknowledged in AR, along with L702H (25%), T878A (14%), H875Y (11%), W742C (8%), W742L (4%), F877L (2%), and T878S (2%). Other ctDNA gene alterations throughout the Guardant assays included TP53 (50%), MYC (34%), BRAF (32%), PIK3CA (29%), MET (25%), CDK6 (26%), EGFR (24%), FGFR1 (21%), and APC (12%).

Many of these non-AR alterations are normally not tissue verified in numerous analysis. AR amplification cosegregated with alterations in MYC (p < .001), BRAF (p < .001), PIK3CA (p < .001), MET (p < .001), CDK6 (p < .001), EGFR (p < .001), FGFR1 (p = .391), and further. Alterations in APC have been significantly associated to mutations in AR (p < .001).Several AR alterations and concomitant non-AR alterations that affiliate with drug resistance have been detected.

These findings current additional insights into the heterogeneity of superior prostate most cancers.

NF-kB p65 Antibody
AF6387	Affbiotech	200ul	EUR 420

NF-kB p65 Antibody
AF6795	Affbiotech	100ul	EUR 420

NF-kB p65 Antibody
AF0874	Affbiotech	200ul	EUR 420

NF-kB p65 Antibody
48676-100ul	SAB	100ul	EUR 399.6

NF-kB p65 Antibody
48676-50ul	SAB	50ul	EUR 286.8

NF-kB p65 Antibody
BF0382	Affbiotech	200ul	EUR 540

pGreenFire1-NF-kB (plasmid)
TR012PA-1	SBI	10 ug	EUR 943.2

pGreenFire1-NF-kB (virus)
TR012VA-1	SBI	>2 x 10^6 IFUs	EUR 943.2

p65 Antibody / NF-kB
R20290-0.1ML	NSJ Bioreagents	100ul	EUR 409

p65 Antibody NF-kB
R30293	NSJ Bioreagents	100 ug	EUR 419

p65 Antibody NF-kB
R30754	NSJ Bioreagents	100 ug	EUR 419

p65 Antibody / NF-kB
RQ4439	NSJ Bioreagents	100ug	EUR 419

p65 Antibody / NF-kB
V9229-100UG	NSJ Bioreagents	100ug	EUR 499
Description: Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor N B (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp B sequence in the immunoglobulin light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NF B is activated and NF B is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.

p65 Antibody / NF-kB
V9229-20UG	NSJ Bioreagents	20ug	EUR 219
Description: Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor N B (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp B sequence in the immunoglobulin light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NF B is activated and NF B is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.

p65 Antibody / NF-kB
V9229SAF-100UG	NSJ Bioreagents	100ug	EUR 499
Description: Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor N B (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp B sequence in the immunoglobulin light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NF B is activated and NF B is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.

p65 Antibody / NF-kB
V9238-100UG	NSJ Bioreagents	100ug	EUR 499
Description: Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor N B (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp B sequence in the immunoglobulin light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NF B is activated and NF B is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.

p65 Antibody / NF-kB
V9238-20UG	NSJ Bioreagents	20ug	EUR 219
Description: Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor N B (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp B sequence in the immunoglobulin light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NF B is activated and NF B is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.

p65 Antibody / NF-kB
V9238SAF-100UG	NSJ Bioreagents	100ug	EUR 499
Description: Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor N B (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp B sequence in the immunoglobulin light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NF B is activated and NF B is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.

NF-kB p65 Blocking Peptide
DF7003-BP	Affbiotech	1mg	EUR 234

NF-kB p65 Conjugated Antibody
C48676	SAB	100ul	EUR 476.4

NF-kB p65 Blocking Peptide
AF0874-BP	Affbiotech	1mg	EUR 234

NF-kB p65 Rabbit pAb
A11202-100ul	Abclonal	100 ul	EUR 369.6

NF-kB p65 Rabbit pAb
A11202-200ul	Abclonal	200 ul	EUR 550.8

NF-kB p65 Rabbit pAb
A11202-20ul	Abclonal	20 ul	EUR 219.6

NF-kB p65 Rabbit pAb
A11202-50ul	Abclonal	50 ul	EUR 267.6

NF-kB p65 Rabbit pAb
A11204-100ul	Abclonal	100 ul	EUR 369.6

NF-kB p65 Rabbit pAb
A11204-200ul	Abclonal	200 ul	EUR 550.8

NF-kB p65 Rabbit pAb
A11204-20ul	Abclonal	20 ul	EUR 219.6

NF-kB p65 Rabbit pAb
A11204-50ul	Abclonal	50 ul	EUR 267.6

NF-kB p65 Mouse mAb
A10609	Abclonal	20 μL	EUR 18

NF-kB p65 Mouse mAb
A10609-100ul	Abclonal	100 ul	EUR 460.8

NF-kB p65 Mouse mAb
A10609-200ul	Abclonal	200 ul	EUR 664.8

NF-kB p65 Mouse mAb
A10609-20ul	Abclonal	20 ul	Ask for price

NF-kB p65 Mouse mAb
A10609-50ul	Abclonal	50 ul	EUR 318

NF-kB p100 (pS872) Antibody
abx011250-100ug	Abbexa	100 ug	EUR 526.8

NF-kB p65 (pS281) Antibody
abx011264-100ug	Abbexa	100 ug	EUR 526.8

NF-kB p65 (pS529) Antibody
abx011265-100ug	Abbexa	100 ug	EUR 526.8

NF-kB p65 (pS311) Antibody
abx011266-100ug	Abbexa	100 ug	EUR 526.8

NF-kB p65 (pS536) Antibody
abx011269-100ug	Abbexa	100 ug	EUR 526.8

NF-kB p65 (pS276) Antibody
abx011270-100ug	Abbexa	100 ug	EUR 526.8

NF-kB p65 (pS468) Antibody
abx011271-100ug	Abbexa	100 ug	EUR 526.8

NF-kB p65 (pT254) Antibody
abx011272-100ug	Abbexa	100 ug	EUR 526.8

NF-kB p65 (pT435) Antibody
abx011273-100ug	Abbexa	100 ug	EUR 526.8

NF-kB p65 Rabbit pAb
A2547-100ul	Abclonal	100 ul	EUR 369.6

NF-kB p65 Rabbit pAb
A2547-200ul	Abclonal	200 ul	EUR 550.8

NF-kB p65 Rabbit pAb
A2547-20ul	Abclonal	20 ul	EUR 219.6

NF-kB p65 Rabbit pAb
A2547-50ul	Abclonal	50 ul	EUR 267.6

NF-kB p65 Rabbit pAb
A16271-100ul	Abclonal	100 ul	EUR 369.6

NF-kB p65 Rabbit pAb
A16271-200ul	Abclonal	200 ul	EUR 550.8

NF-kB p65 Rabbit pAb
A16271-20ul	Abclonal	20 ul	EUR 219.6

NF-kB p65 Rabbit pAb
A16271-50ul	Abclonal	50 ul	EUR 267.6

NF-kB p65 Rabbit pAb
A0450-100ul	Abclonal	100 ul	EUR 369.6

NF-kB p65 Rabbit pAb
A0450-200ul	Abclonal	200 ul	EUR 550.8

NF-kB p65 Rabbit pAb
A0450-20ul	Abclonal	20 ul	Ask for price

NF-kB p65 Rabbit pAb
A0450-50ul	Abclonal	50 ul	Ask for price

NF-kB p65 Blocking Peptide
BF0382-BP	Affbiotech	1mg	EUR 234

NF-kB p65 Polyclonal Antibody
A71090-050	EpiGentek	50 ul	EUR 377.3

NF-kB p65 Polyclonal Antibody
A71090-100	EpiGentek	100 ul	EUR 577.5

NF-kB p65 Polyclonal Antibody
A71091-050	EpiGentek	50 ul	EUR 302.5

NF-kB p65 Polyclonal Antibody
A71091-100	EpiGentek	100 ul	EUR 423.5

NF-kB p65 Polyclonal Antibody
A71092-050	EpiGentek	50 ul	EUR 302.5

NF-kB p65 Polyclonal Antibody
A71092-100	EpiGentek	100 ul	EUR 423.5

NF-kB p65 Polyclonal Antibody
A71094-050	EpiGentek	50 ul	EUR 302.5

NF-kB p65 Polyclonal Antibody
A71094-100	EpiGentek	100 ul	EUR 423.5

RELA Antibody NF-kB p65
R31513	NSJ Bioreagents	100 ug	EUR 419

p65 Antibody / NF-kB (pS529)
RQ4504	NSJ Bioreagents	100ul	EUR 419

NF-kB p65 Polyclonal Antibody
A71090	EpiGentek	EUR 377.30 EUR 577.50	50 ul 100 ul

NF-kB p65 Polyclonal Antibody
A71091	EpiGentek	EUR 302.50 EUR 423.50	50 ul 100 ul

NF-kB p65 Polyclonal Antibody
A71092	EpiGentek	EUR 302.50 EUR 423.50	50 ul 100 ul

NF-kB p65 Polyclonal Antibody
A71094	EpiGentek	EUR 302.50 EUR 423.50	50 ul 100 ul

Phospho-NF-kB p65 (Ser276) Antibody
AF3387	Affbiotech	200ul	EUR 420

Phospho-NF-kB p65 (Ser529) Antibody
AF3388	Affbiotech	200ul	EUR 420

Phospho-NF-kB p65 (Ser311) Antibody
AF3389	Affbiotech	200ul	EUR 420

Phospho-NF-kB p65 (Ser468) Antibody
AF3390	Affbiotech	200ul	EUR 420

Phospho-NF-kB p65 (Thr254) Antibody
AF3391	Affbiotech	200ul	EUR 420

Phospho-NF-kB p65 (Thr435) Antibody
AF3392	Affbiotech	200ul	EUR 420

Phospho-NF-kB p65 (Ser281) Antibody
AF3393	Affbiotech	200ul	EUR 420

Phospho-NF-kB p65 (Ser536) Antibody
AF2006	Affbiotech	200ul	EUR 420

NF-kB p65 Polyclonal Conjugated Antibody
C27518	SAB	100ul	EUR 476.4

NF-kB p65 (Phospho-S529) Antibody
13347-100ul	SAB	100ul	EUR 399.6

NF-kB p65 (Phospho-S529) Antibody
13347-50ul	SAB	50ul	EUR 286.8

NF-kB p65 recombinant monoclonal antibody
A5075	Bimake	100ul X 3	EUR 714
Description: A recombinant monoclonal antibody from rabbit against human NF-kB p65 for WB, IHC, IF,ELISA

NF-kB p100 / p52 (pS865) Antibody
abx011251-100ug	Abbexa	100 ug	EUR 526.8

NF-kB p100 / p52 (pS869) Antibody
abx011252-100ug	Abbexa	100 ug	EUR 526.8

NF-kB p105 / p50 (pS932) Antibody
abx011254-100ug	Abbexa	100 ug	EUR 526.8

NF-kB p105 / p50 (pS893) Antibody
abx011255-100ug	Abbexa	100 ug	EUR 526.8

NF-kB p105 / p50 (pS337) Antibody
abx011256-100ug	Abbexa	100 ug	EUR 526.8

NF-kB p105 / p50 (pS927) Antibody
abx011257-100ug	Abbexa	100 ug	EUR 526.8

NF-kB p105 / p50 (pS907) Antibody
abx011259-100ug	Abbexa	100 ug	EUR 526.8

Anti-NF-kB p65/RELA Antibody
A00284-1	BosterBio	100ug/vial	EUR 400.8

Anti-NF-kB p65/RELA Antibody
PA1125	BosterBio	100ug/vial	EUR 352.8

Anti-NF-kB p65/RELA Antibody
PA1669	BosterBio	100ug/vial	EUR 400.8

Nori Equine NF-kB ELISA Kit
GR106501	Genorise Scientific	96-well	EUR 553.2

Nori Human NF-kB ELISA Kit
GR111033	Genorise Scientific	96-well	EUR 553.2

Nori Bovine NF-kB ELISA Kit
GR112023	Genorise Scientific	96-well	EUR 553.2

Nori Canine NF-kB ELISA Kit
GR115026	Genorise Scientific	96-well	EUR 553.2

Anti-NF-kB p65/RELA Antibody
PB9087	BosterBio	100ug/vial	EUR 352.8

Anti-NF-kB p65/RELA Antibody
PB9324	BosterBio	100ug/vial	EUR 352.8

pGL4.32[luc2P/NF-kB-RE/Hygro]
PVT13580	Lifescience Market	2 ug	EUR 843.6

Anti-NF-kB p65 (Ser316) antibody
STJ120299	St John's Laboratory	100 µl	EUR 631.2

pGreenFire1-NF-kB (plasmid)+ EF1-Neo
TR012PA-N	SBI	10 ug	EUR 943.2

pGreenFire1-NF-kB (plasmid)+ EF1-Puro
TR012PA-P	SBI	10 ug	EUR 943.2

pGreenFire1-NF-kB (virus) + EF1-Neo
TR012VA-N	SBI	>2 x 10^6 IFUs	EUR 943.2

pGreenFire1-NF-kB (virus) + EF1-Puro
TR012VA-P	SBI	>2 x 10^6 IFUs	EUR 943.2

NFKB1 Antibody NF-kB p105/p50
R31223	NSJ Bioreagents	100 ug	EUR 419

Rat Nuclear Factor-kB P65 (NF-kB p65) CLIA Kit
abx196083-96tests	Abbexa	96 tests	EUR 990

ELISA kit for Human Nuclear factor-KB p65 (NF-KB p65)
KTE60811-48T	Abbkine	48T	EUR 424.8
Description: Quantitative sandwich ELISA for measuring Human Nuclear factor-KB p65 (NF-KB p65) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Nuclear factor-KB p65 (NF-KB p65)
KTE60811-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Human Nuclear factor-KB p65 (NF-KB p65) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Nuclear factor-KB p65 (NF-KB p65)
KTE60811-96T	Abbkine	96T	EUR 686.4
Description: Quantitative sandwich ELISA for measuring Human Nuclear factor-KB p65 (NF-KB p65) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Nuclear factor-KB p65 (NF-KB p65)
KTE70510-48T	Abbkine	48T	EUR 424.8
Description: Quantitative sandwich ELISA for measuring Mouse Nuclear factor-KB p65 (NF-KB p65) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Nuclear factor-KB p65 (NF-KB p65)
KTE70510-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Mouse Nuclear factor-KB p65 (NF-KB p65) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Nuclear factor-KB p65 (NF-KB p65)
KTE70510-96T	Abbkine	96T	EUR 686.4
Description: Quantitative sandwich ELISA for measuring Mouse Nuclear factor-KB p65 (NF-KB p65) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

NF-kB p65 (Phospho-S529) Conjugated Antibody
C13347	SAB	100ul	EUR 476.4

Phospho-NF-kB p105 (Ser903) Blocking Peptide
AF8013-BP	Affbiotech	1mg	EUR 234

Phospho-NF-kB p105 (Ser923) Blocking Peptide
AF8014-BP	Affbiotech	1mg	EUR 234

Phospho-NF-kB p100 (Ser872) Blocking Peptide
AF3375-BP	Affbiotech	1mg	EUR 234

[KO Validated] NF-kB p65 Rabbit pAb
A11201-100ul	Abclonal	100 ul	EUR 492

[KO Validated] NF-kB p65 Rabbit pAb
A11201-200ul	Abclonal	200 ul	EUR 685.2

[KO Validated] NF-kB p65 Rabbit pAb
A11201-20ul	Abclonal	20 ul	EUR 265.2

[KO Validated] NF-kB p65 Rabbit pAb
A11201-50ul	Abclonal	50 ul	EUR 344.4

[KO Validated] NF-kB p65 Polyclonal Antibody
27518-100ul	SAB	100ul	EUR 302.4

[KO Validated] NF-kB p65 Polyclonal Antibody
27518-50ul	SAB	50ul	EUR 224.4

[KO Validated] NF-kB p65 Rabbit mAb
A19653	Abclonal	20 μL	EUR 18

[KO Validated] NF-kB p65 Rabbit mAb
A19653-100ul	Abclonal	100 ul	EUR 492

[KO Validated] NF-kB p65 Rabbit mAb
A19653-200ul	Abclonal	200 ul	EUR 685.2

[KO Validated] NF-kB p65 Rabbit mAb
A19653-20ul	Abclonal	20 ul	EUR 265.2

[KO Validated] NF-kB p65 Rabbit mAb
A19653-50ul	Abclonal	50 ul	EUR 344.4

Anti-NF-kB p65 Antibody (Clone#AMC0222)
A2000-100	Biovision	100 µl	EUR 405.6

NF-kB p65 highly active Recombinant Protein
90-348	ProSci	2 ug	EUR 600.9
Description: NF-kappaB is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappaB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric p65-p50 complex is the most abundant complex. The dimers bind at kappaB sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappaB sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappaB complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappaB inhibitor (I-kappaB) family. In a conventional activation pathway, I-kappaB is phosphorylated by I-kappaB kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappaB complex which translocates to the nucleus. NF-kappaB heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappaB p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappaB complex.

NF-kB p50 highly active Recombinant Protein
90-349	ProSci	2 ug	EUR 632.4
Description: NF-kappaB is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappaB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric p65-p50 complex is the most abundant complex. The dimers bind at kappaB sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappaB sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappaB complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappaB inhibitor (I-kappaB) family. In a conventional activation pathway, I-kappaB is phosphorylated by I-kappaB kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappaB complex which translocates to the nucleus. NF-kappaB heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappaB p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3.

Polyclonal NF-KB p100 Antibody (Ab-869)
APR05373G	Leading Biology	0.1ml	EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human NF-KB p100 (Ab-869). This antibody is tested and proven to work in the following applications:

Phospho-NF-kB p65-S311 Rabbit pAb
AP0445-100ul	Abclonal	100 ul	EUR 460.8

Phospho-NF-kB p65-S311 Rabbit pAb
AP0445-200ul	Abclonal	200 ul	EUR 664.8

Phospho-NF-kB p65-S311 Rabbit pAb
AP0445-20ul	Abclonal	20 ul	EUR 219.6

Phospho-NF-kB p65-S311 Rabbit pAb
AP0445-50ul	Abclonal	50 ul	EUR 318

Phospho-NF-kB p65-S536 Rabbit pAb
AP0475-100ul	Abclonal	100 ul	EUR 460.8

Phospho-NF-kB p65-S536 Rabbit pAb
AP0475-200ul	Abclonal	200 ul	EUR 664.8

Phospho-NF-kB p65-S536 Rabbit pAb
AP0475-20ul	Abclonal	20 ul	EUR 219.6

Phospho-NF-kB p65-S536 Rabbit pAb
AP0475-50ul	Abclonal	50 ul	EUR 318

Phospho-NF-kB p65-T254 Rabbit pAb
AP0122-100ul	Abclonal	100 ul	EUR 460.8

Phospho-NF-kB p65-T254 Rabbit pAb
AP0122-200ul	Abclonal	200 ul	EUR 664.8

Phospho-NF-kB p65-T254 Rabbit pAb
AP0122-20ul	Abclonal	20 ul	Ask for price

Phospho-NF-kB p65-T254 Rabbit pAb
AP0122-50ul	Abclonal	50 ul	EUR 318

Phospho-NF-kB p65-S276 Rabbit pAb
AP0123-100ul	Abclonal	100 ul	EUR 460.8

Phospho-NF-kB p65-S276 Rabbit pAb
AP0123-200ul	Abclonal	200 ul	EUR 664.8

Phospho-NF-kB p65-S276 Rabbit pAb
AP0123-20ul	Abclonal	20 ul	EUR 219.6

The purpose was to characterize androgen receptor gene (AR) amplifications and mutations detected in circulating tumor DNA (ctDNA) from victims with prostate most cancers in relation to non-AR gene alterations detected throughout the ctDNA panorama.

The study included 892 victims with prostate most cancers with AR alterations in ctDNA. AR alterations have been significantly associated to completely different gene alterations detected in ctDNA.

The widespread AR mutations found are linked to resistance to abiraterone, enzalutamide, or bicalutamide. Characterization of the circulating AR panorama and gene alterations provides potential additional notion into the somatic genetic heterogeneity of superior prostate most cancers.