Analysis of Epigenetic Alterations in Homologous Recombination DNA Repair Genes in Male Breast Cancer.

BACKGROUNDMale breast most cancers (BC) is a definite neoplasm with low however rising incidence, incessantly identified as superior stage illness. Considering the relevance of altered homologous recombination restore (HRR) in male BC, we aimed to discover the biomarker potential of aberrant promoter methylation of ATMBRCA1PALB2RAD51B, and XRCC3.Formalin-fixed paraffin-embedded (FFPE) tissue samples from 128 male BC sufferers, paired adjoining regular tissue and 19 gynecomastia instances have been collected and assessed by quantitative methylation-specific PCR (qMSP). Non-parametric exams have been used to match methylation ranges between tumor and non-tumor samples and to hunt for associations with clinicopathological variables.

RESULTSOnly RAD51B and XRCC3 disclosed important variations between tumor and gynecomastia (p < 0.0001 and p = 0.020, respectively). Assembled in a panel, RAD51B and XRCC3 promoter methylation discriminated male BC from gynecomastia with 91.5% sensitivity, 89.5% specificity, and 91.2% accuracy.

Human IkB alpha/NFKBIA ELISA Kit

MBS8123962-5x96Tests 5x96Tests
EUR 2395

Human IkB alpha/NFKBIA ELISA Kit

MBS8123962-96Tests 96Tests
EUR 520

Polyclonal NFKBIA / IKB Alpha / IKBA Antibody (Ser32)

APR02414G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human NFKBIA / IKB Alpha / IKBA (Ser32). This antibody is tested and proven to work in the following applications:

Polyclonal NFKBIA / IKB Alpha / IKBA Antibody (C-Terminus)

APR02300G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human NFKBIA / IKB Alpha / IKBA (C-Terminus). This antibody is tested and proven to work in the following applications:

Polyclonal NFKBIA / IKB Alpha / IKBA Antibody (C-Terminus)

APR02424G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human NFKBIA / IKB Alpha / IKBA (C-Terminus). This antibody is tested and proven to work in the following applications:

Active Recombinant Human IkB-alpha/NFKBIA Protein

RP00032 5 μg
EUR 113.75

IKB alpha (NFKBIA) sheep polyclonal antibody, Purified

SP1148P 100 µg Ask for price

IKBE (NFKBIE, NF-kappa-B Inhibitor epsilon, NF-kappa-BIE, I-kappa-B-epsilon, IkB-E, IkB-epsilon, IkappaBepsilon)

MBS626438-005mg 0.05mg
EUR 475

IKBE (NFKBIE, NF-kappa-B Inhibitor epsilon, NF-kappa-BIE, I-kappa-B-epsilon, IkB-E, IkB-epsilon, IkappaBepsilon)

MBS626438-5x005mg 5x0.05mg
EUR 1995

IKB zeta (NFKBIZ) (NM_001005474) Human Over-expression Lysate

LS064332 100ug
EUR 628
Description: Antigen standard for nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta (NFKBIZ)

IKB beta (NFKBIB) (NM_002503) Human Over-expression Lysate

LS004793 100ug
EUR 628
Description: Transient overexpression lysate of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta (NFKBIB), transcript variant 1

IKB beta/NFKBIB Protein, Human, Recombinant (GST Tag)

MBS8118680-01mg 0.1mg
EUR 395

IKB beta/NFKBIB Protein, Human, Recombinant (GST Tag)

MBS8118680-5x01mg 5x0.1mg
EUR 1635

NFkB p100

E8ET1705-45 100ul
EUR 275
Description: Available in various conjugation types.

NFKB p100

MBS8565583-01mL 0.1mL
EUR 345

NFKB p100

MBS8565583-01mLAF405L 0.1mL(AF405L)
EUR 565

NFKB p100

MBS8565583-01mLAF405S 0.1mL(AF405S)
EUR 565

NFKB p100

MBS8565583-01mLAF610 0.1mL(AF610)
EUR 565

NFKB p100

MBS8565583-01mLAF635 0.1mL(AF635)
EUR 565

IKB alpha (NFKBIA) (NM_020529) Human Over-expression Lysate

LS004792 100ug
EUR 628
Description: Transient overexpression lysate of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA)

Recombinant Human IKB alpha/NFKBIA Protein (His Tag)

PKSH030926-50ug 50ug
EUR 732
Description: Human

Recombinant Human IKB alpha / NFKBIA Protein (His tag)

MBS2545594-005mg 0.05mg
EUR 685

Recombinant Human IKB alpha / NFKBIA Protein (His tag)

MBS2545594-5x005mg 5x0.05mg
EUR 3080

IKB beta (NFKBIB) (C-term) rabbit polyclonal antibody

AP07609SU-N 50 µl Ask for price

NFKBIA/IKB Alpha/IKBA Rabbit anti-Mouse Polyclonal Antibody

MBS2403298-006mL 0.06mL
EUR 615

NFKBIA/IKB Alpha/IKBA Rabbit anti-Mouse Polyclonal Antibody

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EUR 2605

IKB alpha (NFKBIA) (C-term) rabbit polyclonal antibody

AP07862SU-N 50 µl Ask for price

Mouse anti Human IkB alpha/NFKBIA Monoclonal Antibody

MBS2543675-006mL 0.06mL
EUR 250

Mouse anti Human IkB alpha/NFKBIA Monoclonal Antibody

MBS2543675-012mL 0.12mL
EUR 370

Mouse anti Human IkB alpha/NFKBIA Monoclonal Antibody

MBS2543675-02mL 0.2mL
EUR 550

Mouse anti Human IkB alpha/NFKBIA Monoclonal Antibody

MBS2543676-006mL 0.06mL
EUR 250

Mouse anti Human IkB alpha/NFKBIA Monoclonal Antibody

MBS2543676-012mL 0.12mL
EUR 370

Mouse anti Human IkB alpha/NFKBIA Monoclonal Antibody

MBS2543676-02mL 0.2mL
EUR 550

NFkB Antibody

GWB-A99D1B 0.1 ml Ask for price

IKB beta (NFKBIB) rabbit polyclonal antibody, Aff - Purified

AP21089PU-N 100 µg Ask for price

IKB alpha (NFKBIA) rabbit polyclonal antibody, Aff - Purified

AP20703PU-N 100 µg Ask for price

IKB alpha (NFKBIA) rabbit polyclonal antibody, Aff - Purified

AP06185PU-N 100 µg Ask for price

IKB alpha (NFKBIA) rabbit polyclonal antibody, Aff - Purified

AP07467PU-N 50 µl Ask for price

IKB alpha (NFKBIA) rabbit polyclonal antibody, Aff - Purified

AP02651PU-N 100 µg Ask for price

IKB alpha (NFKBIA) rabbit polyclonal antibody, Aff - Purified

AP02651PU-S 50 µg Ask for price

IKB alpha (NFKBIA) rabbit polyclonal antibody, Aff - Purified

AP02694PU-N 100 µg Ask for price

IKB alpha (NFKBIA) rabbit polyclonal antibody, Aff - Purified

AP02694PU-S 50 µg Ask for price

IKB epsilon (NFKBIE) rabbit polyclonal antibody, Aff - Purified

AP06186PU-N 100 µg Ask for price

IKB epsilon (NFKBIE) rabbit polyclonal antibody, Aff - Purified

AP02784PU-N 100 µg Ask for price

IKB epsilon (NFKBIE) rabbit polyclonal antibody, Aff - Purified

AP02784PU-S 50 µg Ask for price

IKB alpha (NFKBIA) (C-term) rabbit polyclonal antibody, Serum

R1013 100 µl Ask for price

Rat NFKB 65

QY-E11918 96T
EUR 448.8

IKB beta (NFKBIB) mouse monoclonal antibody, clone 7B4, Ascites

AM06491SU-N 100 µl Ask for price

IKBE, phosphorylated (Ser22) (NFKBIE, NF-kappa-B Inhibitor epsilon, NF-kappa-BIE, I-kappa-B-epsilon, IkB-E, IkB-epsilon, IkappaBepsilon)

MBS624161-005mg 0.05mg
EUR 475

IKBE, phosphorylated (Ser22) (NFKBIE, NF-kappa-B Inhibitor epsilon, NF-kappa-BIE, I-kappa-B-epsilon, IkB-E, IkB-epsilon, IkappaBepsilon)

MBS624161-5x005mg 5x0.05mg
EUR 1995

NFkB p105/p50

E8ET1603-18 100ul
EUR 275
Description: Available in various conjugation types.

NFkB p105 / p50

E8M1505-8 100ul
EUR 275
Description: Available in various conjugation types.

NFkB p105/p50

E8R1309-9 100ul
EUR 275
Description: Available in various conjugation types.

NFkB p105/p50

MBS8534606-01mL 0.1mL
EUR 345

NFkB p105/p50

MBS8534606-01mLAF405L 0.1mL(AF405L)
EUR 565

NFkB p105/p50

MBS8534606-01mLAF405S 0.1mL(AF405S)
EUR 565

NFkB p105/p50

MBS8534606-01mLAF610 0.1mL(AF610)
EUR 565

NFkB p105/p50

MBS8534606-01mLAF635 0.1mL(AF635)
EUR 565

NFkB p105/p50

MBS8534727-01mL 0.1mL
EUR 345

NFkB p105/p50

MBS8534727-01mLAF405L 0.1mL(AF405L)
EUR 565

NFkB p105/p50

MBS8534727-01mLAF405S 0.1mL(AF405S)
EUR 565

NFkB p105/p50

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EUR 565

NFkB p105/p50

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EUR 565

NFkB p105/p50

MBS8533691-01mL 0.1mL
EUR 345

NFkB p105/p50

MBS8533691-01mLAF405L 0.1mL(AF405L)
EUR 565

NFkB p105/p50

MBS8533691-01mLAF405S 0.1mL(AF405S)
EUR 565

NFkB p105/p50

MBS8533691-01mLAF610 0.1mL(AF610)
EUR 565

NFkB p105/p50

MBS8533691-01mLAF635 0.1mL(AF635)
EUR 565

IKB beta (NFKBIB) pSer23 rabbit polyclonal antibody, Aff - Purified

AP02536PU-N 100 µg Ask for price

IKB beta (NFKBIB) pSer23 rabbit polyclonal antibody, Aff - Purified

AP02536PU-S 50 µg Ask for price

IKB alpha (NFKBIA) pTyr42 rabbit polyclonal antibody, Aff - Purified

AP20824PU-N 100 µg Ask for price

IKB alpha (NFKBIA) mouse monoclonal antibody, clone 6A055, Purified

AM00179PU-N 100 µg Ask for price

IKB

EF017836 96 Tests
EUR 826.8

NFkB p65 Antibody

20-abx133308
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NFkB p65 Antibody

20-abx134504
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NFkB p65 Antibody

20-abx134505
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NFkB p65 Antibody

20-abx134506
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NFkB p65 Antibody

abx012273-100ul 100 ul
EUR 493.2

NFkB p65 Antibody

20-abx012874
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NFkB p65 Antibody

20-abx008774
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NFkB p65 Antibody

20-abx008775
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NFkB p65 Antibody

20-abx008776
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NFkB p65 Antibody

20-abx008777
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NFkB p65 Antibody

20-abx008778
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NFkB p65 Antibody

20-abx008779
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NFkB p52 antibody

10R-8543 100 ul
EUR 471.6
Description: Mouse monoclonal NFkB p52 antibody

NFKB p65 antibody

10R-1917 100 ul
EUR 435
Description: Mouse monoclonal NFKB p65 antibody

NFkB p65 antibody

10R-6718 100 ug
EUR 859.2
Description: Mouse monoclonal NFkB p65 antibody

NFkB p65 antibody

10R-7999 100 ug
EUR 630
Description: Mouse monoclonal NFkB p65 antibody

NFKB P52 antibody

20-PR79 100 µL
EUR 748
Description: Rabbit polyclonal NFKB P52 antibody

NFKB p65 antibody

20R-2196 50 ug
EUR 269
Description: Rabbit polyclonal NFKB p65 antibody

NFKB p65 antibody

20R-2913 100 ul
EUR 471.6
Description: Rabbit polyclonal NFkB p65 antibody

NFkB p65 antibody

20R-1437 100 ug
EUR 807.6
Description: Rabbit polyclonal NFkB p65 antibody

NFkB p50 antibody

20R-1520 100 ug
EUR 807.6
Description: Rabbit polyclonal NFkB p50 antibody

NFkB p65 Antibody

3038-100 each
EUR 379.2

NFkB p65 Antibody

3038-30T each
EUR 175.2

NFkB p50 Antibody

3354R-100 each
EUR 379.2

NFkB p50 Antibody

3354R-30T each
EUR 175.2

NFkB P65 Antibody

E76020 100μl
EUR 225
Description: Available in various conjugation types.

NFkB p65 Antibody

E2220013 100ug
EUR 225
Description: Available in various conjugation types.

NFkB p65 antibody

70R-11575 100 ug
EUR 343
Description: Rabbit polyclonal NFkB p65 antibody

NFkB p50 antibody

70R-11768 100 ug
EUR 343
Description: Rabbit polyclonal NFkB p50 antibody

NFkB p65 antibody

70R-36057 100 ug
EUR 294
Description: Rabbit polyclonal NFkB p65 antibody

NFkB p65 antibody

70R-37450 100 ug
EUR 260
Description: Rabbit Polyclonal NFkB p65 antibody

NFkB p65 antibody

70R-37451 100 ug
EUR 260
Description: Rabbit Polyclonal NFkB p65 antibody

NFkB p65 antibody

70R-37452 100 ug
EUR 260
Description: Rabbit Polyclonal NFkB p65 antibody

NFkB p65 antibody

70R-37453 100 ug
EUR 260
Description: Rabbit Polyclonal NFkB p65 antibody

NFkB p65 antibody

70R-37454 100 ug
EUR 260
Description: Rabbit Polyclonal NFkB p65 antibody

NFkB p50 Antibody

GWB-516B45 0.1 ml Ask for price

NFkB p50, Antibody

GWB-549338 1 ml Ask for price

NFkB p50 Antibody

GWB-57C6C0 0.05 ml Ask for price

NFkB p65 Antibody

GWB-59AB2A 0.1 mg Ask for price

NFkB p65 Antibody

GWB-954311 0.1 ml Ask for price

NFkB p50, Antibody

GWB-F8446B 7 ml Ask for price

NFkB p65 Antibody

GWB-FDFDFB 0.05 ml Ask for price

NFkB p65, Antibody

GWB-B0BC81 1 ml Ask for price

NFkB p65, Antibody

GWB-C15EEA 7 ml Ask for price

NFkB p65 Antibody

abx012874-100g 100 µg
EUR 237.5

NFkB p65 Antibody

abx012874-10g 10 µg
EUR 43.75

NFkB p65 Antibody

abx012874-200g 200 µg
EUR 312.5

NFkB p65 Antibody

abx012273-100g 100 µg Ask for price

NFkB p65 Antibody

abx012273-10g 10 µg
EUR 362.5

NFkB p65 Antibody

abx012273-200g 200 µg Ask for price

NFkB P65 Antibody

MBS857741-01mL 0.1mL
EUR 305

NFkB P65 Antibody

MBS857741-01mLAF405L 0.1mL(AF405L)
EUR 565

NFkB P65 Antibody

MBS857741-01mLAF405S 0.1mL(AF405S)
EUR 565

NFkB P65 Antibody

MBS857741-01mLAF610 0.1mL(AF610)
EUR 565

NFkB P65 Antibody

MBS857741-01mLAF635 0.1mL(AF635)
EUR 565

NFKB p65 antibody

MBS830878-01mL 0.1mL
EUR 745

NFKB p65 antibody

MBS830878-5x01mL 5x0.1mL
EUR 3205

NFkB p65 Antibody

MBS8504743-01mg 0.1mg
EUR 305

NFkB p65 Antibody

MBS8504743-01mLAF405L 0.1mL(AF405L)
EUR 565

NFkB p65 Antibody

MBS8504743-01mLAF405S 0.1mL(AF405S)
EUR 565

NFkB p65 Antibody

MBS8504743-01mLAF610 0.1mL(AF610)
EUR 565

NFkB p65 Antibody

MBS8504743-01mLAF635 0.1mL(AF635)
EUR 565

NFkB p65 Antibody

MBS5311137-01mg 0.1mg
EUR 470

NFkB p65 Antibody

MBS5311137-5x01mg 5x0.1mg
EUR 2080

NFkB p50 Antibody

MBS5311271-01mg 0.1mg
EUR 470

NFkB p50 Antibody

MBS5311271-5x01mg 5x0.1mg
EUR 2080

NFKB p65 antibody

MBS5309652-005mg 0.05mg
EUR 485

NFKB p65 antibody

MBS5309652-5x005mg 5x0.05mg
EUR 2045

NFKB P52 antibody

MBS534424-01mL 0.1mL
EUR 1355

NFKB P52 antibody

MBS534424-5x01mL 5x0.1mL
EUR 5945

NFkB p65 Antibody

MBS5313790-01mg 0.1mg
EUR 420

NFkB p65 Antibody

MBS5313790-5x01mg 5x0.1mg
EUR 1740

NFkB p65 Antibody

MBS5313791-01mg 0.1mg
EUR 420

NFkB p65 Antibody

MBS5313791-5x01mg 5x0.1mg
EUR 1740

NFkB p65 Antibody

MBS5313792-01mg 0.1mg
EUR 420

NFkB p65 Antibody

MBS5313792-5x01mg 5x0.1mg
EUR 1740

NFkB p65 Antibody

MBS5313793-01mg 0.1mg
EUR 420

NFkB p65 Antibody

MBS5313793-5x01mg 5x0.1mg
EUR 1740

NFkB p65 Antibody

MBS5313794-01mg 0.1mg
EUR 420

NFkB p65 Antibody

MBS5313794-5x01mg 5x0.1mg
EUR 1740

NFkB p105 Antibody

20-abx133154
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NFkB p100 Antibody

20-abx133260
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NFkB p105 Antibody

20-abx007474
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NFkB p100 Antibody

20-abx008937
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NFkB p105 Antibody

20-abx008939
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NFKB p100 antibody

20R-2199 50 ug
EUR 269
Description: Rabbit polyclonal NFKB p100 antibody

NFKB p100 antibody

20R-2200 50 ug
EUR 269
Description: Rabbit polyclonal NFKB p100 antibody

NFKB p105 antibody

20R-2201 50 ug
EUR 269
Description: Rabbit polyclonal NFKB p105 antibody

NFKB p105 antibody

20R-2202 50 ug
EUR 269
Description: Rabbit polyclonal NFKB p105 antibody

NFKB p105 antibody

20R-2203 50 ug
EUR 269
Description: Rabbit polyclonal NFKB p105 antibody

NFKB p105 antibody

20R-2402 50 ug
EUR 269
Description: Rabbit polyclonal NFKB p105 antibody

NFKB p100 antibody

20R-2450 50 ug
EUR 269
Description: Rabbit polyclonal NFKB p100 antibody

NFKB p105 antibody

20R-2459 50 ug
EUR 269
Description: Rabbit polyclonal NFKB p105 antibody

NFkB p105 antibody

20R-1755 200 ug
EUR 807.6
Description: Rabbit polyclonal NFkB p105 antibody

NFKB p105 antibody

20R-2086 50 ug
EUR 269
Description: Rabbit polyclonal NFKB p105 antibody

NFKB p105 antibody

20R-2132 50 ug
EUR 269
Description: Rabbit polyclonal NFKB p105 antibody

NFkB p105 Antibody

3897-200 each
EUR 379.2

NFkB p105 Antibody

3897-30T each
EUR 175.2

NFkB p100 Antibody

49633 100ul
EUR 499

Moreover, promoter methylation ranges have been decrease in paired non-tumor tissues, evaluating to tumor samples. No associations have been discovered between epigenetic alterations and clinicopathological options, in addition to with RAD51 and XRCC3 immunoexpression and methylation ranges.

CONCLUSIONQuantitative promoter methylation of RAD51B and XRCC3 constitutes a promising and correct biomarker for male BC. Validation in bigger sequence and in liquid biopsies is warranted to verify its usefulness in detection and monitoring settings.

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