Analysis of Epigenetic Alterations in Homologous Recombination DNA Repair Genes in Male Breast Cancer.

BACKGROUNDMale breast most cancers (BC) is a definite neoplasm with low however rising incidence, incessantly identified as superior stage illness. Considering the relevance of altered homologous recombination restore (HRR) in male BC, we aimed to discover the biomarker potential of aberrant promoter methylation of ATM, BRCA1, PALB2, RAD51B, and XRCC3.Formalin-fixed paraffin-embedded (FFPE) tissue samples from 128 male BC sufferers, paired adjoining regular tissue and 19 gynecomastia instances have been collected and assessed by quantitative methylation-specific PCR (qMSP). Non-parametric exams have been used to match methylation ranges between tumor and non-tumor samples and to hunt for associations with clinicopathological variables.

RESULTSOnly RAD51B and XRCC3 disclosed important variations between tumor and gynecomastia (p < 0.0001 and p = 0.020, respectively). Assembled in a panel, RAD51B and XRCC3 promoter methylation discriminated male BC from gynecomastia with 91.5% sensitivity, 89.5% specificity, and 91.2% accuracy.

Recombinant Human IkB-alpha/NFKBIA Protein
RP00032 5 μg
EUR 74.39

IKB beta (NFKBIB) (NM_002503) Human Recombinant Protein
E45H41005M5 20 ug
EUR 785.42

IKB beta (NFKBIB) (NM_001001716) Human Recombinant Protein
E45H35126M5 20 ug
EUR 785.42

IKB beta (NFKBIB) (NM_002503) Human Recombinant Protein
PROTQ15653 Regular: 20ug
EUR 1249
Description: Recombinant protein of human nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta (NFKBIB), transcript variant 1

IKB alpha (NFKBIA) (NM_020529) Human Recombinant Protein
E45H41858M5 20 ug
EUR 785.42

Polyclonal NFKBIA / IKB Alpha / IKBA Antibody (C-Terminus)
APR02300G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human NFKBIA / IKB Alpha / IKBA (C-Terminus). This antibody is tested and proven to work in the following applications:

Polyclonal NFKBIA / IKB Alpha / IKBA Antibody (C-Terminus)
APR02424G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human NFKBIA / IKB Alpha / IKBA (C-Terminus). This antibody is tested and proven to work in the following applications:

IKB epsilon (NFKBIE) (NM_004556) Human Recombinant Protein
E45H31732E1 50 ug
EUR 552.5

IKB alpha (NFKBIA) sheep polyclonal antibody, Purified
SP1148P 100 µg Ask for price

NFkB p100
E8ET1705-45 100ul
EUR 275
Description: Available in various conjugation types.

NFKB p100
MBS8565583-01mL 0.1mL
EUR 345

NFKB p100
MBS8565583-01mLAF405L 0.1mL(AF405L)
EUR 565

NFKB p100
MBS8565583-01mLAF405S 0.1mL(AF405S)
EUR 565

NFKB p100
MBS8565583-01mLAF610 0.1mL(AF610)
EUR 565

NFKB p100
MBS8565583-01mLAF635 0.1mL(AF635)
EUR 565

IKBE (NFKBIE, NF-kappa-B Inhibitor epsilon, NF-kappa-BIE, I-kappa-B-epsilon, IkB-E, IkB-epsilon, IkappaBepsilon)
MBS626438-005mg 0.05mg
EUR 475

IKBE (NFKBIE, NF-kappa-B Inhibitor epsilon, NF-kappa-BIE, I-kappa-B-epsilon, IkB-E, IkB-epsilon, IkappaBepsilon)
MBS626438-5x005mg 5x0.05mg
EUR 1995

IKB beta/NFKBIB Protein, Human, Recombinant (GST Tag)
E45H51410E6-100 100 ug
EUR 1046.77

IKB beta (NFKBIB) (NM_002503) Human Over-expression Lysate
E45H06216-2 each
EUR 395

IKB beta (NFKBIB) (NM_001001716) Human Over-expression Lysate
E45H03263-2 each
EUR 395

IKB zeta (NFKBIZ) (NM_001005474) Human Over-expression Lysate
E45H03556-2 each
EUR 395

IKB zeta (NFKBIZ) (NM_031419) Human Over-expression Lysate
E45H12524-2 each
EUR 395

IKB zeta (NFKBIZ) (NM_001005474) Human Over-expression Lysate
LS064332 100ug
EUR 628
Description: Antigen standard for nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta (NFKBIZ)

IKB beta (NFKBIB) (NM_002503) Human Over-expression Lysate
LS004793 100ug
EUR 628
Description: Transient overexpression lysate of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta (NFKBIB), transcript variant 1

IKB beta/NFKBIB Protein, Human, Recombinant (GST Tag)
MBS8118680-01mg 0.1mg
EUR 395

IKB beta/NFKBIB Protein, Human, Recombinant (GST Tag)
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EUR 1635

IKB alpha (NFKBIA) (NM_020529) Human Over-expression Lysate
E45H11188-2 each
EUR 395

IKB alpha (NFKBIA) (NM_020529) Human Over-expression Lysate
LS004792 100ug
EUR 628
Description: Transient overexpression lysate of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA)

Recombinant Human IKB alpha / NFKBIA Protein (His tag)
MBS2545594-005mg 0.05mg
EUR 685

Recombinant Human IKB alpha / NFKBIA Protein (His tag)
MBS2545594-5x005mg 5x0.05mg
EUR 3080

Recombinant Human IKB alpha/NFKBIA Protein (His Tag)
PKSH030926-50ug 50ug
EUR 732
Description: Human

NFkB Antibody
GWB-A99D1B 0.1 ml Ask for price

IKB beta (NFKBIB) (C-term) rabbit polyclonal antibody
AP07609SU-N 50 µl Ask for price

IKB zeta (NFKBIZ) Mouse Monoclonal Antibody [Clone:1E8]
E45M11165 100 ug
EUR 595

IKB zeta (NFKBIZ) Mouse Monoclonal Antibody [Clone 1E8]
E45M11165V-2 50 ul
EUR 195

NFKBIA/IKB Alpha/IKBA Rabbit anti-Mouse Polyclonal Antibody
MBS2403298-006mL 0.06mL
EUR 615

NFKBIA/IKB Alpha/IKBA Rabbit anti-Mouse Polyclonal Antibody
MBS2403298-5x006mL 5x0.06mL
EUR 2605

IKB alpha (NFKBIA) (C-term) rabbit polyclonal antibody
AP07862SU-N 50 µl Ask for price

IKB alpha (NFKBIA) Mouse Monoclonal Antibody [Clone:1D4]
E45M14179 100 ug
EUR 595

IKB alpha (NFKBIA) Mouse Monoclonal Antibody [Clone 1D4]
E45M14179V-2 50 ul
EUR 195

IKB alpha (NFKBIA) Mouse Monoclonal Antibody [Clone:2F5]
E45M14182 100 ug
EUR 595

IKB alpha (NFKBIA) Mouse Monoclonal Antibody [Clone 2F5]
E45M14182V-2 50 ul
EUR 195

Mouse anti Human IkB alpha/NFKBIA Monoclonal Antibody
MBS2543675-006mL 0.06mL
EUR 250

Mouse anti Human IkB alpha/NFKBIA Monoclonal Antibody
MBS2543675-012mL 0.12mL
EUR 370

Mouse anti Human IkB alpha/NFKBIA Monoclonal Antibody
MBS2543675-02mL 0.2mL
EUR 550

Mouse anti Human IkB alpha/NFKBIA Monoclonal Antibody
MBS2543676-006mL 0.06mL
EUR 250

Mouse anti Human IkB alpha/NFKBIA Monoclonal Antibody
MBS2543676-012mL 0.12mL
EUR 370

Mouse anti Human IkB alpha/NFKBIA Monoclonal Antibody
MBS2543676-02mL 0.2mL
EUR 550

IKB epsilon (NFKBIE) Mouse Monoclonal Antibody [Clone:4F7]
E45M19786 100 ug
EUR 595

IKB epsilon (NFKBIE) Mouse Monoclonal Antibody [Clone 4F7]
E45M19786V-2 50 ul
EUR 195

IKB epsilon (NFKBIE) Mouse Monoclonal Antibody [Clone:4D1]
E45M19790 100 ug
EUR 595

IKB epsilon (NFKBIE) Mouse Monoclonal Antibody [Clone 4D1]
E45M19790V-2 50 ul
EUR 195

IKB epsilon (NFKBIE) Mouse Monoclonal Antibody [Clone:1E5]
E45M19804 100 ug
EUR 595

IKB epsilon (NFKBIE) Mouse Monoclonal Antibody [Clone 1E5]
E45M19804V-2 50 ul
EUR 195

IKB epsilon (NFKBIE) Mouse Monoclonal Antibody [Clone:6H8]
E45M19826 100 ug
EUR 595

IKB epsilon (NFKBIE) Mouse Monoclonal Antibody [Clone 6H8]
E45M19826V-2 50 ul
EUR 195

IKB epsilon (NFKBIE) Mouse Monoclonal Antibody [Clone:6G9]
E45M19827 100 ug
EUR 595

IKB epsilon (NFKBIE) Mouse Monoclonal Antibody [Clone 6G9]
E45M19827V-2 50 ul
EUR 195

IKB epsilon (NFKBIE) Mouse Monoclonal Antibody [Clone:6D8]
E45M19832 100 ug
EUR 595

IKB epsilon (NFKBIE) Mouse Monoclonal Antibody [Clone 6D8]
E45M19832V-2 50 ul
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IKB beta (NFKBIB) rabbit polyclonal antibody, Aff - Purified
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IKB epsilon (NFKBIE) Mouse Monoclonal Antibody [Clone:5D11]
E45M19845 100 ug
EUR 595

IKB epsilon (NFKBIE) Mouse Monoclonal Antibody [Clone 5D11]
E45M19845V-2 50 ul
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IKB alpha (NFKBIA) rabbit polyclonal antibody, Aff - Purified
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IKB epsilon (NFKBIE) rabbit polyclonal antibody, Aff - Purified
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Rat NFKB 65
QY-E11918 96T
EUR 420

IKB alpha (NFKBIA) (C-term) rabbit polyclonal antibody, Serum
R1013 100 µl Ask for price

NFkB p105/p50
E8ET1603-18 100ul
EUR 275
Description: Available in various conjugation types.

NFkB p105 / p50
E8M1505-8 100ul
EUR 275
Description: Available in various conjugation types.

NFkB p105/p50
E8R1309-9 100ul
EUR 275
Description: Available in various conjugation types.

NFkB EMSA Kit
GS-0030 30
EUR 374.5
Description: Nuclear factor of kappa light polypeptide gene

NFkB p105/p50
MBS8533691-01mL 0.1mL
EUR 345

NFkB p105/p50
MBS8533691-01mLAF405L 0.1mL(AF405L)
EUR 565

NFkB p105/p50
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NFkB p105/p50
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NFkB p105/p50
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NFkB p105/p50
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EUR 345

NFkB p105/p50
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EUR 565

NFkB p105/p50
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EUR 565

NFkB p105/p50
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EUR 565

NFkB p105/p50
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NFkB p105/p50
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EUR 345

NFkB p105/p50
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EUR 565

NFkB p105/p50
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EUR 565

NFkB p105/p50
MBS8534727-01mLAF610 0.1mL(AF610)
EUR 565

NFkB p105/p50
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EUR 565

IKB beta (NFKBIB) mouse monoclonal antibody, clone 7B4, Ascites
AM06491SU-N 100 µl Ask for price

IKBE, phosphorylated (Ser22) (NFKBIE, NF-kappa-B Inhibitor epsilon, NF-kappa-BIE, I-kappa-B-epsilon, IkB-E, IkB-epsilon, IkappaBepsilon)
MBS624161-005mg 0.05mg
EUR 475

IKBE, phosphorylated (Ser22) (NFKBIE, NF-kappa-B Inhibitor epsilon, NF-kappa-BIE, I-kappa-B-epsilon, IkB-E, IkB-epsilon, IkappaBepsilon)
MBS624161-5x005mg 5x0.05mg
EUR 1995

NFkB probe & plate
PP-0001 96
EUR 113

NFkB p65 Antibody
20-abx008774
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NFkB p65 Antibody
20-abx008775
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NFkB p65 Antibody
20-abx008776
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NFkB p65 Antibody
20-abx008777
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NFkB p65 Antibody
20-abx008778
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NFkB p65 Antibody
20-abx008779
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NFkB p65 Antibody
abx012273-100g 100 µg Ask for price

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abx012273-100ul 100 ul
EUR 493.2

NFkB p65 Antibody
abx012273-10g 10 µg
EUR 362.5

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NFkB p65 Antibody
abx012874-100g 100 µg
EUR 237.5

NFkB p65 Antibody
20-abx012874
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NFkB p65 Antibody
abx012874-10g 10 µg
EUR 43.75

NFkB p65 Antibody
abx012874-200g 200 µg
EUR 312.5

NFkB p65 antibody
70R-11575 100 ug
EUR 343
Description: Rabbit polyclonal NFkB p65 antibody

NFkB p50 antibody
70R-11768 100 ug
EUR 343
Description: Rabbit polyclonal NFkB p50 antibody

NFkB p65 antibody
70R-36057 100 ug
EUR 294
Description: Rabbit polyclonal NFkB p65 antibody

NFkB p65 antibody
70R-37450 100 ug
EUR 260
Description: Rabbit Polyclonal NFkB p65 antibody

NFkB p65 antibody
70R-37451 100 ug
EUR 260
Description: Rabbit Polyclonal NFkB p65 antibody

NFkB p65 antibody
70R-37452 100 ug
EUR 260
Description: Rabbit Polyclonal NFkB p65 antibody

NFkB p65 antibody
70R-37453 100 ug
EUR 260
Description: Rabbit Polyclonal NFkB p65 antibody

NFkB p65 antibody
70R-37454 100 ug
EUR 260
Description: Rabbit Polyclonal NFkB p65 antibody

NFkB p65 Antibody
3038-100 each
EUR 379.2

NFkB p65 Antibody
3038-30T each
EUR 175.2

NFkB p50 Antibody
3354R-100 each
EUR 379.2

NFkB p50 Antibody
3354R-30T each
EUR 175.2

NFkB p52 antibody
10R-8543 100 ul
EUR 471.6
Description: Mouse monoclonal NFkB p52 antibody

NFkB p65 antibody
20R-1437 100 ug
EUR 807.6
Description: Rabbit polyclonal NFkB p65 antibody

NFkB p50 antibody
20R-1520 100 ug
EUR 807.6
Description: Rabbit polyclonal NFkB p50 antibody

NFKB p65 antibody
20R-2196 50 ug
EUR 269
Description: Rabbit polyclonal NFKB p65 antibody

NFKB p65 antibody
20R-2913 100 ul
EUR 471.6
Description: Rabbit polyclonal NFkB p65 antibody

NFKB p65 antibody
10R-1917 100 ul
EUR 435
Description: Mouse monoclonal NFKB p65 antibody

NFkB p65 antibody
10R-6718 100 ug
EUR 859.2
Description: Mouse monoclonal NFkB p65 antibody

NFkB p65 antibody
10R-7999 100 ug
EUR 630
Description: Mouse monoclonal NFkB p65 antibody

NFKB P52 antibody
20-PR79 100 µL
EUR 748
Description: Rabbit polyclonal NFKB P52 antibody

NFkB p65 Antibody
20-abx133308
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NFkB p65 Antibody
20-abx134504
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NFkB p65 Antibody
20-abx134505
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NFkB p65 Antibody
20-abx134506
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NFkB p50 Antibody
GWB-516B45 0.1 ml Ask for price

NFkB p50, Antibody
GWB-549338 1 ml Ask for price

NFkB p50 Antibody
GWB-57C6C0 0.05 ml Ask for price

NFkB p65 Antibody
GWB-59AB2A 0.1 mg Ask for price

NFkB P65 Antibody
E76020 100μl
EUR 225
Description: Available in various conjugation types.

NFkB p65, Antibody
GWB-B0BC81 1 ml Ask for price

NFkB p65 Antibody
E2220013 100ug
EUR 225
Description: Available in various conjugation types.

NFkB p65 Antibody
GWB-954311 0.1 ml Ask for price

NFkB p50, Antibody
GWB-F8446B 7 ml Ask for price

NFkB p65 Antibody
GWB-FDFDFB 0.05 ml Ask for price

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GWB-C15EEA 7 ml Ask for price

NFKB p65 antibody
MBS5309652-005mg 0.05mg
EUR 485

NFKB p65 antibody
MBS5309652-5x005mg 5x0.05mg
EUR 2045

NFkB p65 Antibody
MBS5311137-01mg 0.1mg
EUR 470

NFkB p65 Antibody
MBS5311137-5x01mg 5x0.1mg
EUR 2080

NFkB p50 Antibody
MBS5311271-01mg 0.1mg
EUR 470

NFkB p50 Antibody
MBS5311271-5x01mg 5x0.1mg
EUR 2080

NFKB P52 antibody
MBS534424-01mL 0.1mL
EUR 1355

NFKB P52 antibody
MBS534424-5x01mL 5x0.1mL
EUR 5945

NFkB p65 Antibody
MBS5313790-01mg 0.1mg
EUR 420

NFkB p65 Antibody
MBS5313790-5x01mg 5x0.1mg
EUR 1740

NFkB p65 Antibody
MBS5313791-01mg 0.1mg
EUR 420

NFkB p65 Antibody
MBS5313791-5x01mg 5x0.1mg
EUR 1740

NFkB p65 Antibody
MBS5313792-01mg 0.1mg
EUR 420

NFkB p65 Antibody
MBS5313792-5x01mg 5x0.1mg
EUR 1740

NFkB p65 Antibody
MBS5313793-01mg 0.1mg
EUR 420

NFkB p65 Antibody
MBS5313793-5x01mg 5x0.1mg
EUR 1740

NFkB p65 Antibody
MBS5313794-01mg 0.1mg
EUR 420

NFkB p65 Antibody
MBS5313794-5x01mg 5x0.1mg
EUR 1740

NFkB p65 Antibody
MBS8504743-01mg 0.1mg
EUR 305

NFkB p65 Antibody
MBS8504743-01mLAF405L 0.1mL(AF405L)
EUR 565

NFkB p65 Antibody
MBS8504743-01mLAF405S 0.1mL(AF405S)
EUR 565

NFkB p65 Antibody
MBS8504743-01mLAF610 0.1mL(AF610)
EUR 565

NFkB p65 Antibody
MBS8504743-01mLAF635 0.1mL(AF635)
EUR 565

NFKB p65 antibody
MBS830878-01mL 0.1mL
EUR 745

Moreover, promoter methylation ranges have been decrease in paired non-tumor tissues, evaluating to tumor samples. No associations have been discovered between epigenetic alterations and clinicopathological options, in addition to with RAD51 and XRCC3 immunoexpression and methylation ranges.

CONCLUSIONQuantitative promoter methylation of RAD51B and XRCC3 constitutes a promising and correct biomarker for male BC. Validation in bigger sequence and in liquid biopsies is warranted to verify its usefulness in detection and monitoring settings.

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