DNA Barcoding in Nonhuman Primates Reveals Important Limitations in Retrovirus Integration Site Analysis.

DNA Barcoding in Nonhuman Primates Reveals Important Limitations in Retrovirus Integration Site Analysis.

In vivo monitoring of retrovirus-tagged blood stem and progenitor cells is used to check hematopoiesis. Two strategies are used most incessantly: sequencing the locus of retrovirus insertion, termed integration web site evaluation, or retrovirus DNA barcode sequencing.

Of these, integration web site evaluation is at present the one out there method for monitoring clonal swimming pools in sufferers handled with retrovirus-modified blood cells.

A key query is how these two strategies examine in their potential to detect and quantify clonal contributions. In this research, we assessed each strategies concurrently in a clinically related nonhuman primate mannequin of autologous, myeloablative transplantation.

Our knowledge show that each strategies observe ample clones; nonetheless, DNA barcode sequencing is no less than 5-fold extra environment friendly than integration web site evaluation. Using computational simulation to establish the sources of low effectivity, we establish sampling depth as the main issue.

We present that the sampling required for integration web site evaluation to realize minimal protection of the true clonal pool is probably going prohibitive, particularly in circumstances of low gene-modified cell engraftment. We additionally present that early subsampling of various blood cell lineages provides worth to clone monitoring data in phrases of security and hematopoietic biology.

Our evaluation demonstrates DNA barcode sequencing as a helpful information to maximise integration web site evaluation interpretation in gene remedy sufferers.

Integrated DNA methylation evaluation reveals a possible position for ANKRD30B in Williams syndrome.

Williams syndrome (WS) is a uncommon genetic dysfunction, brought on by a microdeletion on the 7q11.23 area. WS reveals a large spectrum of options together with hypersociability, which contrasts with social deficits sometimes related to autism spectrum issues. The phenotypic variability in WS probably entails epigenetic modifications; nonetheless, the character of those occasions stays unclear.

 DNA Barcoding in Nonhuman Primates Reveals Important Limitations in Retrovirus Integration Site Analysis.
DNA Barcoding in Nonhuman Primates Reveals Important Limitations in Retrovirus Integration Site Analysis.

To higher perceive the position of epigenetics in WS phenotypes, we built-in DNA methylation and gene expression profiles in blood from sufferers with WS and controls.

From these research, 380 differentially methylated positions (DMPs), situated all through the genome, have been recognized. Systems-level evaluation revealed a number of co-methylation modules linked to intermediate phenotypes of WS, with the top-scoring module associated to neurogenesis and growth of the central nervous system.

NF-kB p65 Antibody

DF7003 200ul
EUR 420

NF-kB p65 Antibody

AF0874 200ul
EUR 420

NF-kB p65 Antibody

AF0874-100ul 100ul
EUR 280

NF-kB p65 Antibody

AF0874-200ul 200ul
EUR 350

NF-kB p65 Antibody

AF6387 200ul
EUR 420

NF-kB p65 Antibody

AF6387-100ul 100ul
EUR 280

NF-kB p65 Antibody

AF6387-200ul 200ul
EUR 350

NF-kB p65 Antibody

AF6795 100ul
EUR 420

NF-kB p65 Antibody

AF6795-100ul 100ul
EUR 280

NF-kB p65 Antibody

AF6795-200ul 200ul
EUR 350

NF-kB p65 Antibody

AF5006 200ul
EUR 420

NF-kB p65 Antibody

AF5006-100ul 100ul
EUR 280

NF-kB p65 Antibody

AF5006-200ul 200ul
EUR 350

NF-kB p65 Antibody

BF0382 200ul
EUR 540

p65 Antibody / NF-kB

RQ4439 100ug
EUR 356.15
Description: Transcription factor p65, also known as NFKB3 or NF-kB p65, is a protein that in humans is encoded by the RELA gene. It is mapped to 11q13.1. NFKB is an essential transcription factor complex involved in all types of cellular processes, including cellular metabolism, chemotaxis, etc, and it may play a role in inflammatory conditions of the peripheral nervous system. Phosphorylation and acetylation of NFKB3 are crucial post-translational modifications required for NFKB activation. It has also been shown to modulate immune responses, and activation of NFKB3 is positively associated with multiple types of cancer. In addition to that, NFKB3 antagonizes TNFR1-JNK proliferative signals in epidermis and plays a nonredundant role in restraining epidermal growth.

p65 Antibody / NF-kB

R20290-0.1ML 100ul
EUR 347.65
Description: This recombinant p65 antibody reacts to human transcription factor p65 (NFkB p65 subunit).

p65 Antibody NF-kB

R30293 100 ug
EUR 356.15
Description: The p65 (RELA) heterodimer is the most abundant form of NF-KB. This gene is located on 11q13, which consists of 10 exons and spans about 8.1 kb of DNA. In rat sciatic nerves, the expression of the activated p65 subunit of NFKB was high in the nuclei of premyelinating Schwann cells and then progressively declined until it was nearly absent in adults. The transcriptional activity of NF-kappa-B is stimulated upon phosphorylation of its p65 subunit on serine-276 by protein kinase A(PKA). The transcriptional coactivator CBP/p300 associates with NF-kappa-B through 2 sites, an N-terminal domain that interacts with the C-terminal region of the unphosphorylated protein, and a second domain that only interacts with p65 phosphorylated on serine-276.

p65 Antibody NF-kB

R30754 100 ug
EUR 356.15
Description: RELA, also called NFKB3 or NFKB, p65 subunit is part of the NF-kB complex. The complex is inhibited by I-kappa-B proteins, which inactivates NFkB by trapping it in the cytoplasm. The p65 heterodimer is the most abundant form of NF-kB. It is a nonhistone substrate of HDAC3 and that IKBA-dependent nuclear export of the HDAC3-deacetylated RELA replenishes the depleted cytoplasmic pool of latent NFKB-IKBA complexes for subsequent NF-kB responses. Its nucleocytoplasmic redistribution coincided with export of PPARG, and immunoprecipitation analysis indicated that PPARG-RELA association was dependent on the PPARG C-terminal ligand-binding domain. IKK-dependent phosphorylation of RELA on Ser468 enhanced binding of GCN5 to RELA and its ubiquitination.

pGreenFire1-NF-kB (plasmid)

TR012PA-1 10 ug
EUR 720

pGreenFire1-NF-kB (virus)

TR012VA-1 >2 x 10^6 IFUs
EUR 720

NF-kB Rabbit pAb

E2350196 100ul
EUR 225
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

p65 Antibody / NF-kB

V9229-100UG 100ug
EUR 349.3
Description: Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor N B (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp B sequence in the immunoglobulin light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NF B is activated and NF B is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.

p65 Antibody / NF-kB

V9229-20UG 20ug
EUR 153.3
Description: Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor N B (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp B sequence in the immunoglobulin light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NF B is activated and NF B is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.

p65 Antibody / NF-kB

V9229SAF-100UG 100ug
EUR 349.3
Description: Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor N B (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp B sequence in the immunoglobulin light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NF B is activated and NF B is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.

p65 Antibody / NF-kB

V9238-100UG 100ug
EUR 349.3
Description: Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor N B (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp B sequence in the immunoglobulin light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NF B is activated and NF B is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.

p65 Antibody / NF-kB

V9238-20UG 20ug
EUR 153.3
Description: Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor N B (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp B sequence in the immunoglobulin light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NF B is activated and NF B is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.

p65 Antibody / NF-kB

V9238SAF-100UG 100ug
EUR 349.3
Description: Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor N B (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp B sequence in the immunoglobulin light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NF B is activated and NF B is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.

NF-kB p65 Polyclonal Antibody

E916271 100ul
EUR 225
Description: Available in various conjugation types.

Phospho-NF-kB p65 (S529)

E8ET1604-27 100ul
EUR 275
Description: Available in various conjugation types.

NF-kB p65 Blocking Peptide

DF7003-BP 1mg
EUR 234

NF-KB p100 Rabbit mAb

E2R25145 100ul
EUR 255
Description: Available in various conjugation types.

NF-KB p100 Rabbit mAb

E2R25146 100ul
EUR 255
Description: Available in various conjugation types.

NF-KB p65 Rabbit mAb

E2R25149 100ul
EUR 255
Description: Available in various conjugation types.

NF-KB p65 Rabbit mAb

E2R25150 100ul
EUR 255
Description: Available in various conjugation types.

NF-kB p65 Blocking Peptide

AF0874-BP 1mg
EUR 234

NF-kB p65 Mouse mAb

A10609-100ul 100 ul
EUR 460.8

NF-kB p65 Mouse mAb

A10609-200ul 200 ul
EUR 664.8

NF-kB p65 Mouse mAb

A10609-20ul 20 ul Ask for price

NF-kB p65 Mouse mAb

A10609-50ul 50 ul
EUR 318

NF-kB p65 Rabbit pAb

A11202-100ul 100 ul
EUR 369.6

NF-kB p65 Rabbit pAb

A11202-200ul 200 ul
EUR 550.8

NF-kB p65 Rabbit pAb

A11202-20ul 20 ul
EUR 219.6

NF-kB p65 Rabbit pAb

A11202-50ul 50 ul
EUR 267.6

NF-kB p65 Rabbit pAb

A11204-100ul 100 ul
EUR 369.6

NF-kB p65 Rabbit pAb

A11204-200ul 200 ul
EUR 550.8

NF-kB p65 Rabbit pAb

A11204-20ul 20 ul
EUR 219.6

NF-kB p65 Rabbit pAb

A11204-50ul 50 ul
EUR 267.6

NF-kB p65 Rabbit pAb

A16271-100ul 100 ul
EUR 369.6

NF-kB p65 Rabbit pAb

A16271-200ul 200 ul
EUR 550.8

NF-kB p65 Rabbit pAb

A16271-20ul 20 ul
EUR 219.6

NF-kB p65 Rabbit pAb

A16271-50ul 50 ul
EUR 267.6

NF-kB p65 Rabbit pAb

A2547-100ul 100 ul
EUR 369.6

NF-kB p65 Rabbit pAb

A2547-200ul 200 ul
EUR 550.8

NF-kB p65 Rabbit pAb

A2547-20ul 20 ul
EUR 219.6

NF-kB p65 Rabbit pAb

A2547-50ul 50 ul
EUR 267.6

NF-kB p65 Blocking Peptide

BF0382-BP 1mg
EUR 234

NF-kB p65 Conjugated Antibody

C48676 100ul
EUR 476.4

NF-kB p65 Rabbit pAb

A0450-100ul 100 ul
EUR 369.6

NF-kB p65 Rabbit pAb

A0450-200ul 200 ul
EUR 550.8

NF-kB p65 Rabbit pAb

A0450-20ul 20 ul Ask for price

NF-kB p65 Rabbit pAb

A0450-50ul 50 ul Ask for price

NF-kB p100 (pS872) Antibody

abx011250-100ug 100 ug
EUR 526.8

NF-kB p65 (pS281) Antibody

abx011264-100ug 100 ug
EUR 526.8

NF-kB p65 (pS529) Antibody

abx011265-100ug 100 ug
EUR 526.8

NF-kB p65 (pS311) Antibody

abx011266-100ug 100 ug
EUR 526.8

NF-kB p65 (pS536) Antibody

abx011269-100ug 100 ug
EUR 526.8

NF-kB p65 (pS276) Antibody

abx011270-100ug 100 ug
EUR 526.8

NF-kB p65 (pS468) Antibody

abx011271-100ug 100 ug
EUR 526.8

NF-kB p65 (pT254) Antibody

abx011272-100ug 100 ug
EUR 526.8

NF-kB p65 (pT435) Antibody

abx011273-100ug 100 ug
EUR 526.8

p65 Antibody / NF-kB (pS529)

RQ4504 100ul
EUR 356.15
Description: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells. [UniProt]

RELA Antibody NF-kB p65

R31513 100 ug
EUR 356.15
Description: Transcription factor p65, also known as NFKB3 or NF-kB p65, is a protein that in humans is encoded by the RELA gene. It is mapped to 11q13.1. RELA is an essential transcription factor complex involved in all types of cellular processes, including cellular metabolism, chemotaxis, etc, and it may play a role in inflammatory conditions of the peripheral nervous system. Phosphorylation and acetylation of RELA are crucial post-translational modifications required for NFkB activation. It has also been shown to modulate immune responses, and activation of the protein is positively associated with multiple types of cancer. In addition, RELA antagonizes TNFR1-JNK proliferative signals in epidermis and plays a nonredundant role in restraining epidermal growth.

NF-kB p65 Polyclonal Antibody

A71090 50 μl
EUR 557

NF-kB p65 Polyclonal Antibody

A71091 50 μl
EUR 408

NF-kB p65 Polyclonal Antibody

A71092 50 μl
EUR 408

NF-kB p65 Polyclonal Antibody

A71094 50 μl
EUR 408

NF-kB p65 (Ab-435)

ANTY021012 100ug
EUR 259

NF-kB p65 (Ab-468)

ANTY021013 100ug
EUR 259

NF-kB p65 (Ab-529)

ANTY021210 100ug
EUR 259

NF-KB p105 Rabbit mAb

E2R380694 100ul
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NF-KB p65 Mouse mAb

E2222013 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NF-KB p105 Mouse mAb

E2222549 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NF-kB p65 Polyclonal Antibody

E-AB-93051-120uL 120uL
EUR 320
Description: Unconjugated

NF-kB p65 Polyclonal Antibody

E-AB-93051-200uL 200uL
EUR 530
Description: Unconjugated

NF-kB p65 Polyclonal Antibody

E-AB-93051-60uL 60uL
EUR 200
Description: Unconjugated

NF-kB p65 Polyclonal Antibody

E-AB-93051-each each Ask for price
Description: Unconjugated

NF-kB p65 Polyclonal Antibody

E-AB-93162-120uL 120uL
EUR 320
Description: Unconjugated

NF-kB p65 Polyclonal Antibody

E-AB-93162-200uL 200uL
EUR 530
Description: Unconjugated

NF-kB p65 Polyclonal Antibody

E-AB-93162-60uL 60uL
EUR 200
Description: Unconjugated

NF-kB p65 Polyclonal Antibody

E-AB-93162-each each Ask for price
Description: Unconjugated

NF-kB p65 (Phospho-S529) Antibody

13347 100ul
EUR 429

NF-kB p65 (Phospho-S529) Antibody

13347-100ul 100ul
EUR 399.6

NF-kB p65 (Phospho-S529) Antibody

13347-50ul 50ul
EUR 286.8

Nori Canine NF-kB ELISA Kit

GR115026 96-well
EUR 461

Nori Human NF-kB ELISA Kit

GR111033 96-well
EUR 461

Nori Bovine NF-kB ELISA Kit

GR112023 96-well
EUR 461

Nori Equine NF-kB ELISA Kit

GR106501 96-well
EUR 461

Phospho-NF-kB p65 (Ser536) Antibody

AF2006 200ul
EUR 420

Phospho-NF-kB p65 (Ser536) Antibody

AF2006-100ul 100ul
EUR 280

Phospho-NF-kB p65 (Ser536) Antibody

AF2006-200ul 200ul
EUR 350

Phospho-NF-kB p65 (Ser276) Antibody

AF3387 200ul
EUR 420

Phospho-NF-kB p65 (Ser276) Antibody

AF3387-100ul 100ul
EUR 280

Phospho-NF-kB p65 (Ser276) Antibody

AF3387-200ul 200ul
EUR 350

Phospho-NF-kB p65 (Ser529) Antibody

AF3388 200ul
EUR 420

Phospho-NF-kB p65 (Ser529) Antibody

AF3388-100ul 100ul
EUR 280

Phospho-NF-kB p65 (Ser529) Antibody

AF3388-200ul 200ul
EUR 350

Phospho-NF-kB p65 (Ser311) Antibody

AF3389 200ul
EUR 420

Phospho-NF-kB p65 (Ser311) Antibody

AF3389-100ul 100ul
EUR 280

Phospho-NF-kB p65 (Ser311) Antibody

AF3389-200ul 200ul
EUR 350

Phospho-NF-kB p65 (Ser468) Antibody

AF3390 200ul
EUR 420

Phospho-NF-kB p65 (Ser468) Antibody

AF3390-100ul 100ul
EUR 280

Phospho-NF-kB p65 (Ser468) Antibody

AF3390-200ul 200ul
EUR 350

Phospho-NF-kB p65 (Thr254) Antibody

AF3391 200ul
EUR 420

Phospho-NF-kB p65 (Thr254) Antibody

AF3391-100ul 100ul
EUR 280

Phospho-NF-kB p65 (Thr254) Antibody

AF3391-200ul 200ul
EUR 350

Phospho-NF-kB p65 (Thr435) Antibody

AF3392 200ul
EUR 420

Phospho-NF-kB p65 (Thr435) Antibody

AF3392-100ul 100ul
EUR 280

Phospho-NF-kB p65 (Thr435) Antibody

AF3392-200ul 200ul
EUR 350

Phospho-NF-kB p65 (Ser281) Antibody

AF3393 200ul
EUR 420

Phospho-NF-kB p65 (Ser281) Antibody

AF3393-100ul 100ul
EUR 280

Phospho-NF-kB p65 (Ser281) Antibody

AF3393-200ul 200ul
EUR 350

Anti-NF-kB p65/RELA Antibody

A00284-1 100ug/vial
EUR 400.8

NF-kB p65/RelA Mouse mAb

A10609 20 μL
EUR 128.7
Description: Recombinant fusion protein containing a sequence corresponding to amino acids 399-514 of human STK33 (Q9BYT3).

NF-kB p65/RelA Rabbit mAb

A19653 20 μL
EUR 1557.4
Description: A synthetic peptide corresponding to a sequence within amino acids 368-467 of human IRF6 (O14896).

NF-kB p65/RelA Mouse mAb

A18210 1000μL
EUR 323.7
Description: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human IL10 (P22301).

NF-kB p65 recombinant monoclonal antibody

A5075 100ul X 3
EUR 714
Description: A recombinant monoclonal antibody from rabbit against human NF-kB p65 for WB, IHC, IF,ELISA

NF-kB p65 Rabbit Polyclonal Antibody

53227 100ul
EUR 439

NF-kB p65 Rabbit Polyclonal Antibody

53228 100ul
EUR 439

NF-kB p65 Rabbit Polyclonal Antibody

54171 100ul
EUR 439

NF-kB p65 Polyclonal Conjugated Antibody

C27518 100ul
EUR 476.4

Phospho-NF-kB p65-S536 antibody

CAF50663-100ug 100ug
EUR 390

NF-kB p100 / p52 (pS865) Antibody

abx011251-100ug 100 ug
EUR 526.8

NF-kB p100 / p52 (pS869) Antibody

abx011252-100ug 100 ug
EUR 526.8

NF-kB p105 / p50 (pS932) Antibody

abx011254-100ug 100 ug
EUR 526.8

NF-kB p105 / p50 (pS893) Antibody

abx011255-100ug 100 ug
EUR 526.8

NF-kB p105 / p50 (pS337) Antibody

abx011256-100ug 100 ug
EUR 526.8

NF-kB p105 / p50 (pS927) Antibody

abx011257-100ug 100 ug
EUR 526.8

NF-kB p105 / p50 (pS907) Antibody

abx011259-100ug 100 ug
EUR 526.8

Anti-NF-kB p65 (Ser316) antibody

STJ120299 100 µl
EUR 631.2

Mouse monoclonal NF-kB p65 antibody

TA319553 100 µg Ask for price

Nuclear Factor NF-KB Inhibitor SN50

H-6052.0500 0.5mg
EUR 327.6
Description: Sum Formula: C129H230N36O29S; CAS# [213546-53-3] net

Nuclear Factor NF-KB Inhibitor SN50

H-6052.1000 1.0mg
EUR 544.8
Description: Sum Formula: C129H230N36O29S; CAS# [213546-53-3] net

pGL4.32[luc2P/NF-kB-RE/Hygro]

PVT13580 2 ug
EUR 843.6

NFKB1 Antibody NF-kB p105/p50

R31223 100 ug
EUR 356.15
Description: NF-kappa-B p105/p50, also called EBP-1 is a protein that in humans is encoded by the NFKB1 gene. By fluorescence in situ hybridization, the gene was assigned to human chromosome 4q24. NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing.

Anti-NF-kB p65/RELA Antibody

PB9087 100ug/vial
EUR 352.8

Anti-NF-kB p65/RELA Antibody

PB9324 100ug/vial
EUR 352.8

Anti-NF-kB p65/RELA Antibody

PA1669 100ug/vial
EUR 400.8

Recombinant Human NF-kB p65 Protein

RP02998 100μg
EUR 260

pGreenFire1-NF-kB (plasmid)+ EF1-Neo

TR012PA-N 10 ug
EUR 720

pGreenFire1-NF-kB (plasmid)+ EF1-Puro

TR012PA-P 10 ug
EUR 720

pGreenFire1-NF-kB (virus) + EF1-Neo

TR012VA-N >2 x 10^6 IFUs
EUR 720

pGreenFire1-NF-kB (virus) + EF1-Puro

TR012VA-P >2 x 10^6 IFUs
EUR 720

NF-kB p100/p52 (Ab-869)

ANTY021016 100ug
EUR 259

NF-KB p100/p52 Mouse mAb

E2222640 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NF-KB p65 Mouse Monoclonal Antibody

E10G20661 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NF-KB p65 Mouse Monoclonal Antibody

E10G20665 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NF-KB p100 Rabbit Monoclonal Antibody

E10G21748 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NF-KB p100 Rabbit Monoclonal Antibody

E10G21749 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NF-KB p65 Rabbit Monoclonal Antibody

E10G22659 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NF-KB p65 Rabbit Monoclonal Antibody

E10G22716 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NF-KB p100 Rabbit Polyclonal Antibody

E10G23471 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NF-KB p65 Rabbit Polyclonal Antibody

E10G23542 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NF-KB p65 Rabbit Polyclonal Antibody

E10G23547 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NF-KB p65 Rabbit Polyclonal Antibody

E10G23599 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NF-kB p65/RelA Polyclonal Antibody

E-AB-93150-120uL 120uL
EUR 320
Description: Unconjugated

NF-kB p65/RelA Polyclonal Antibody

E-AB-93150-200uL 200uL
EUR 530
Description: Unconjugated

Notably, ANKRD30B, a promising hub gene, was considerably hypermethylated in blood and downregulated in mind tissue from people with WS. Most CpG websites of ANKRD30B in blood have been considerably correlated with mind areas.

Furthermore, analyses of gene regulatory networks (GRNs) yielded grasp regulator transcription elements related to WS. Taken collectively, this systems-level method highlights the position of epigenetics in WS, and offers a doable rationalization for the advanced phenotypes noticed in sufferers with WS.

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