DNA Barcoding in Nonhuman Primates Reveals Important Limitations in Retrovirus Integration Site Analysis.

DNA Barcoding in Nonhuman Primates Reveals Important Limitations in Retrovirus Integration Site Analysis.

In vivo monitoring of retrovirus-tagged blood stem and progenitor cells is used to check hematopoiesis. Two strategies are used most incessantly: sequencing the locus of retrovirus insertion, termed integration web site evaluation, or retrovirus DNA barcode sequencing.

Of these, integration web site evaluation is at present the one out there method for monitoring clonal swimming pools in sufferers handled with retrovirus-modified blood cells.

A key query is how these two strategies examine in their potential to detect and quantify clonal contributions. In this research, we assessed each strategies concurrently in a clinically related nonhuman primate mannequin of autologous, myeloablative transplantation.

Our knowledge show that each strategies observe ample clones; nonetheless, DNA barcode sequencing is no less than 5-fold extra environment friendly than integration web site evaluation. Using computational simulation to establish the sources of low effectivity, we establish sampling depth as the main issue.

We present that the sampling required for integration web site evaluation to realize minimal protection of the true clonal pool is probably going prohibitive, particularly in circumstances of low gene-modified cell engraftment. We additionally present that early subsampling of various blood cell lineages provides worth to clone monitoring data in phrases of security and hematopoietic biology.

Our evaluation demonstrates DNA barcode sequencing as a helpful information to maximise integration web site evaluation interpretation in gene remedy sufferers.

Integrated DNA methylation evaluation reveals a possible position for ANKRD30B in Williams syndrome.

Williams syndrome (WS) is a uncommon genetic dysfunction, brought on by a microdeletion on the 7q11.23 area. WS reveals a large spectrum of options together with hypersociability, which contrasts with social deficits sometimes related to autism spectrum issues. The phenotypic variability in WS probably entails epigenetic modifications; nonetheless, the character of those occasions stays unclear.

 DNA Barcoding in Nonhuman Primates Reveals Important Limitations in Retrovirus Integration Site Analysis.
DNA Barcoding in Nonhuman Primates Reveals Important Limitations in Retrovirus Integration Site Analysis.

To higher perceive the position of epigenetics in WS phenotypes, we built-in DNA methylation and gene expression profiles in blood from sufferers with WS and controls.

From these research, 380 differentially methylated positions (DMPs), situated all through the genome, have been recognized. Systems-level evaluation revealed a number of co-methylation modules linked to intermediate phenotypes of WS, with the top-scoring module associated to neurogenesis and growth of the central nervous system.

NF-kB p65

MBS8533687-01mLAF610 0.1mL(AF610)
EUR 565

NF-kB p65

MBS8533687-01mLAF635 0.1mL(AF635)
EUR 565

pBD-NF-kB

PVTY00604 2ug
EUR 280

NF-kB p65 (Nuclear Factor kB)

MBS602308-01mg 0.1mg
EUR 825

NF-kB p65 (Nuclear Factor kB)

MBS602308-5x01mg 5x0.1mg
EUR 3560

NF-kB p65 Antibody

48676 100ul
EUR 499

NF-kB p65 Antibody

48676-100ul 100ul
EUR 399.6

NF-kB p65 Antibody

48676-50ul 50ul
EUR 286.8

NF-kB p65 Antibody

DF7003 200ul
EUR 420

NF-kB p65 Antibody

BF0382 200ul
EUR 540

NF-kB p65 Antibody

AF5006 200ul
EUR 420

NF-kB p65 Antibody

AF5006-100ul 100ul
EUR 280

NF-kB p65 Antibody

AF5006-200ul 200ul
EUR 350

NF-kB p65 Antibody

AF0874 200ul
EUR 420

NF-kB p65 Antibody

AF0874-100ul 100ul
EUR 280

NF-kB p65 Antibody

AF0874-200ul 200ul
EUR 350

NF-kB p65 Antibody

AF6387 200ul
EUR 420

NF-kB p65 Antibody

AF6387-100ul 100ul
EUR 280

NF-kB p65 Antibody

AF6387-200ul 200ul
EUR 350

NF-kB p65 Antibody

AF6795 100ul
EUR 420

NF-kB p65 Antibody

AF6795-100ul 100ul
EUR 280

NF-kB p65 Antibody

AF6795-200ul 200ul
EUR 350

p65 Antibody / NF-kB

R20290-0.1ML 100ul
EUR 347.65
Description: This recombinant p65 antibody reacts to human transcription factor p65 (NFkB p65 subunit).

p65 Antibody NF-kB

R30293 100 ug
EUR 356.15
Description: The p65 (RELA) heterodimer is the most abundant form of NF-KB. This gene is located on 11q13, which consists of 10 exons and spans about 8.1 kb of DNA. In rat sciatic nerves, the expression of the activated p65 subunit of NFKB was high in the nuclei of premyelinating Schwann cells and then progressively declined until it was nearly absent in adults. The transcriptional activity of NF-kappa-B is stimulated upon phosphorylation of its p65 subunit on serine-276 by protein kinase A(PKA). The transcriptional coactivator CBP/p300 associates with NF-kappa-B through 2 sites, an N-terminal domain that interacts with the C-terminal region of the unphosphorylated protein, and a second domain that only interacts with p65 phosphorylated on serine-276.

p65 Antibody NF-kB

R30754 100 ug
EUR 356.15
Description: RELA, also called NFKB3 or NFKB, p65 subunit is part of the NF-kB complex. The complex is inhibited by I-kappa-B proteins, which inactivates NFkB by trapping it in the cytoplasm. The p65 heterodimer is the most abundant form of NF-kB. It is a nonhistone substrate of HDAC3 and that IKBA-dependent nuclear export of the HDAC3-deacetylated RELA replenishes the depleted cytoplasmic pool of latent NFKB-IKBA complexes for subsequent NF-kB responses. Its nucleocytoplasmic redistribution coincided with export of PPARG, and immunoprecipitation analysis indicated that PPARG-RELA association was dependent on the PPARG C-terminal ligand-binding domain. IKK-dependent phosphorylation of RELA on Ser468 enhanced binding of GCN5 to RELA and its ubiquitination.

p65 Antibody / NF-kB

RQ4439 100ug
EUR 356.15
Description: Transcription factor p65, also known as NFKB3 or NF-kB p65, is a protein that in humans is encoded by the RELA gene. It is mapped to 11q13.1. NFKB is an essential transcription factor complex involved in all types of cellular processes, including cellular metabolism, chemotaxis, etc, and it may play a role in inflammatory conditions of the peripheral nervous system. Phosphorylation and acetylation of NFKB3 are crucial post-translational modifications required for NFKB activation. It has also been shown to modulate immune responses, and activation of NFKB3 is positively associated with multiple types of cancer. In addition to that, NFKB3 antagonizes TNFR1-JNK proliferative signals in epidermis and plays a nonredundant role in restraining epidermal growth.

pGreenFire1-NF-kB (plasmid)

TR012PA-1 10 ug
EUR 720

pGreenFire1-NF-kB (virus)

TR012VA-1 >2 x 10^6 IFUs
EUR 720

NF-kB Rabbit pAb

E2350196 100ul
EUR 225
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

p65 Antibody / NF-kB

V9229-100UG 100ug
EUR 349.3
Description: Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor N B (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp B sequence in the immunoglobulin light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NF B is activated and NF B is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.

p65 Antibody / NF-kB

V9229-20UG 20ug
EUR 153.3
Description: Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor N B (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp B sequence in the immunoglobulin light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NF B is activated and NF B is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.

p65 Antibody / NF-kB

V9229SAF-100UG 100ug
EUR 349.3
Description: Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor N B (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp B sequence in the immunoglobulin light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NF B is activated and NF B is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.

p65 Antibody / NF-kB

V9238-100UG 100ug
EUR 349.3
Description: Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor N B (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp B sequence in the immunoglobulin light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NF B is activated and NF B is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.

p65 Antibody / NF-kB

V9238-20UG 20ug
EUR 153.3
Description: Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor N B (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp B sequence in the immunoglobulin light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NF B is activated and NF B is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.

p65 Antibody / NF-kB

V9238SAF-100UG 100ug
EUR 349.3
Description: Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor N B (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp B sequence in the immunoglobulin light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NF B is activated and NF B is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins of the same size have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.

NF-kB p65 Antibody

MBS9435517-005mL 0.05mL
EUR 325

NF-kB p65 Antibody

MBS9435517-01mL 0.1mL
EUR 435

NF-kB p65 Antibody

MBS9435517-5x01mL 5x0.1mL
EUR 1810

NF-kB p65 Antibody

MBS9613816-01mL 0.1mL
EUR 260

NF-kB p65 Antibody

MBS9613816-02mL 0.2mL
EUR 305

NF-kB p65 Antibody

MBS9613816-5x02mL 5x0.2mL
EUR 1220

NF-kB p65 Antibody

BF0382-100ul 100ul
EUR 210
Description: WB,ELISA

NF-kB p65 Antibody

BF0382-200ul 200ul Ask for price
Description: WB,ELISA

NF-kB p65 Antibody

BF0382-50ul 50ul
EUR 150
Description: WB,ELISA

NF-kB p65 Antibody

DF7003-100ul 100ul
EUR 168
Description: WB,IHC,IF/ICC,ELISA(peptide)

NF-kB p65 Antibody

DF7003-200ul 200ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA(peptide)

NF-kB p65 (Nuclear Factor kB) (AP)

MBS6257891-01mL 0.1mL
EUR 1105

NF-kB p65 (Nuclear Factor kB) (AP)

MBS6257891-5x01mL 5x0.1mL
EUR 4830

NF-kB p65 (Nuclear Factor kB) (APC)

MBS6258100-01mL 0.1mL
EUR 1105

NF-kB p65 (Nuclear Factor kB) (APC)

MBS6258100-5x01mL 5x0.1mL
EUR 4830

NF-kB p65 (Nuclear Factor kB) (Biotin)

MBS6258308-01mL 0.1mL
EUR 1105

NF-kB p65 (Nuclear Factor kB) (Biotin)

MBS6258308-5x01mL 5x0.1mL
EUR 4830

NF-kB p65 (Nuclear Factor kB) (FITC)

MBS6258517-01mL 0.1mL
EUR 1105

NF-kB p65 (Nuclear Factor kB) (FITC)

MBS6258517-5x01mL 5x0.1mL
EUR 4830

NF-kB p65 (Nuclear Factor kB) (HRP)

MBS6258725-01mL 0.1mL
EUR 1105

NF-kB p65 (Nuclear Factor kB) (HRP)

MBS6258725-5x01mL 5x0.1mL
EUR 4830

NF-kB p65 (Nuclear Factor kB)-PE

MBS6258933-01mL 0.1mL
EUR 1105

NF-kB p65 (Nuclear Factor kB)-PE

MBS6258933-5x01mL 5x0.1mL
EUR 4830

NF-kB p65 phosphorylated (Ser276) (Nuclear Factor kB)

MBS620815-01mg 0.1mg
EUR 610

NF-kB p65 phosphorylated (Ser276) (Nuclear Factor kB)

MBS620815-5x01mg 5x0.1mg
EUR 2600

NF-kB p65 (Nuclear Factor kB) (MaxLight 405)

MBS6259142-01mL 0.1mL
EUR 1105

NF-kB p65 (Nuclear Factor kB) (MaxLight 405)

MBS6259142-5x01mL 5x0.1mL
EUR 4830

NF-kB p65 (Nuclear Factor kB) (MaxLight 490)

MBS6259351-01mL 0.1mL
EUR 1105

NF-kB p65 (Nuclear Factor kB) (MaxLight 490)

MBS6259351-5x01mL 5x0.1mL
EUR 4830

NF-kB p65 (Nuclear Factor kB) (MaxLight 550)

MBS6259560-01mL 0.1mL
EUR 1105

NF-kB p65 (Nuclear Factor kB) (MaxLight 550)

MBS6259560-5x01mL 5x0.1mL
EUR 4830

NF-kB p65 (Nuclear Factor kB) (MaxLight 650)

MBS6259769-01mL 0.1mL
EUR 1105

NF-kB p65 (Nuclear Factor kB) (MaxLight 650)

MBS6259769-5x01mL 5x0.1mL
EUR 4830

NF-kB p65 (Nuclear Factor kB) (MaxLight 750)

MBS6259978-01mL 0.1mL
EUR 1105

NF-kB p65 (Nuclear Factor kB) (MaxLight 750)

MBS6259978-5x01mL 5x0.1mL
EUR 4830

NF-kB p65 Mouse mAb

A10609-100ul 100 ul
EUR 460.8

NF-kB p65 Mouse mAb

A10609-200ul 200 ul
EUR 664.8

NF-kB p65 Mouse mAb

A10609-20ul 20 ul Ask for price

NF-kB p65 Mouse mAb

A10609-50ul 50 ul
EUR 318

NF-kB p65 Rabbit pAb

A0450-200ul 200 ul
EUR 550.8

NF-kB p65 Rabbit pAb

A0450-20ul 20 ul Ask for price

NF-kB p65 Rabbit pAb

A11202-100ul 100 ul
EUR 369.6

NF-kB p65 Rabbit pAb

A11202-200ul 200 ul
EUR 550.8

NF-kB p65 Rabbit pAb

A11202-20ul 20 ul
EUR 219.6

NF-kB p65 Rabbit pAb

A11202-50ul 50 ul
EUR 267.6

NF-kB p65 Rabbit pAb

A11204-100ul 100 ul
EUR 369.6

NF-kB p65 Rabbit pAb

A11204-200ul 200 ul
EUR 550.8

NF-kB p65 Rabbit pAb

A11204-20ul 20 ul
EUR 219.6

NF-kB p65 Rabbit pAb

A11204-50ul 50 ul
EUR 267.6

NF-kB p100 (pS872) Antibody

abx011250-100ug 100 ug
EUR 526.8

NF-kB p65 (pS281) Antibody

abx011264-100ug 100 ug
EUR 526.8

NF-kB p65 (pS529) Antibody

abx011265-100ug 100 ug
EUR 526.8

NF-kB p65 (pS311) Antibody

abx011266-100ug 100 ug
EUR 526.8

NF-kB p65 (pS536) Antibody

abx011269-100ug 100 ug
EUR 526.8

NF-kB p65 (pS276) Antibody

abx011270-100ug 100 ug
EUR 526.8

NF-kB p65 (pS468) Antibody

abx011271-100ug 100 ug
EUR 526.8

NF-kB p65 (pT254) Antibody

abx011272-100ug 100 ug
EUR 526.8

NF-kB p65 (pT435) Antibody

abx011273-100ug 100 ug
EUR 526.8

NF-kB p65 Blocking Peptide

DF7003-BP 1mg
EUR 234

Phospho-NF-kB p65 (S529)

E8ET1604-27 100ul
EUR 275
Description: Available in various conjugation types.

NF-kB p65 Polyclonal Antibody

E916271 100ul
EUR 225
Description: Available in various conjugation types.

NF-KB p100 Rabbit mAb

E2R25145 100ul
EUR 255
Description: Available in various conjugation types.

NF-KB p100 Rabbit mAb

E2R25146 100ul
EUR 255
Description: Available in various conjugation types.

NF-KB p65 Rabbit mAb

E2R25149 100ul
EUR 255
Description: Available in various conjugation types.

NF-KB p65 Rabbit mAb

E2R25150 100ul
EUR 255
Description: Available in various conjugation types.

NF-kB p65 Blocking Peptide

BF0382-BP 1mg
EUR 234

NF-kB p65 Conjugated Antibody

C48676 100ul
EUR 476.4

NF-kB p65 Rabbit pAb

A2547-100ul 100 ul
EUR 369.6

NF-kB p65 Rabbit pAb

A2547-200ul 200 ul
EUR 550.8

NF-kB p65 Rabbit pAb

A2547-20ul 20 ul
EUR 219.6

NF-kB p65 Rabbit pAb

A2547-50ul 50 ul
EUR 267.6

NF-kB p65 Rabbit pAb

A16271-100ul 100 ul
EUR 369.6

NF-kB p65 Rabbit pAb

A16271-200ul 200 ul
EUR 550.8

NF-kB p65 Rabbit pAb

A16271-20ul 20 ul
EUR 219.6

NF-kB p65 Rabbit pAb

A16271-50ul 50 ul
EUR 267.6

NF-kB p65 Blocking Peptide

AF0874-BP 1mg
EUR 234

NF-kB p65 Polyclonal Antibody

E-AB-93051-120uL 120uL
EUR 320
Description: Unconjugated

NF-kB p65 Polyclonal Antibody

E-AB-93051-200uL 200uL
EUR 530
Description: Unconjugated

NF-kB p65 Polyclonal Antibody

E-AB-93051-60uL 60uL
EUR 200
Description: Unconjugated

NF-kB p65 Polyclonal Antibody

E-AB-93051-each each Ask for price
Description: Unconjugated

NF-kB p65 Polyclonal Antibody

E-AB-93162-120uL 120uL
EUR 320
Description: Unconjugated

NF-kB p65 Polyclonal Antibody

E-AB-93162-200uL 200uL
EUR 530
Description: Unconjugated

NF-kB p65 Polyclonal Antibody

E-AB-93162-60uL 60uL
EUR 200
Description: Unconjugated

NF-kB p65 Polyclonal Antibody

E-AB-93162-each each Ask for price
Description: Unconjugated

RELA Antibody NF-kB p65

R31513 100 ug
EUR 356.15
Description: Transcription factor p65, also known as NFKB3 or NF-kB p65, is a protein that in humans is encoded by the RELA gene. It is mapped to 11q13.1. RELA is an essential transcription factor complex involved in all types of cellular processes, including cellular metabolism, chemotaxis, etc, and it may play a role in inflammatory conditions of the peripheral nervous system. Phosphorylation and acetylation of RELA are crucial post-translational modifications required for NFkB activation. It has also been shown to modulate immune responses, and activation of the protein is positively associated with multiple types of cancer. In addition, RELA antagonizes TNFR1-JNK proliferative signals in epidermis and plays a nonredundant role in restraining epidermal growth.

p65 Antibody / NF-kB (pS529)

RQ4504 100ul
EUR 356.15
Description: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells. [UniProt]

NF-kB p65 Polyclonal Antibody

A71090 50 μl
EUR 557

NF-kB p65 Polyclonal Antibody

A71091 50 μl
EUR 408

NF-kB p65 Polyclonal Antibody

A71092 50 μl
EUR 408

NF-kB p65 Polyclonal Antibody

A71094 50 μl
EUR 408

NF-kB p65 (Ab-435)

ANTY021012 100ug
EUR 259

NF-kB p65 (Ab-468)

ANTY021013 100ug
EUR 259

NF-kB p65 (Ab-529)

ANTY021210 100ug
EUR 259

NF-KB p65 Mouse mAb

E2222013 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NF-KB p105 Mouse mAb

E2222549 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NF-KB p105 Rabbit mAb

E2R380694 100ul
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NF-kB p65 Polyclonal Antibody

MBS8578690-01mL 0.1mL
EUR 305

NF-kB p65 Polyclonal Antibody

MBS8578690-01mLAF405L 0.1mL(AF405L)
EUR 565

NF-kB p65 Polyclonal Antibody

MBS8578690-01mLAF405S 0.1mL(AF405S)
EUR 565

NF-kB p65 Polyclonal Antibody

MBS8578690-01mLAF610 0.1mL(AF610)
EUR 565

NF-kB p65 Polyclonal Antibody

MBS8578690-01mLAF635 0.1mL(AF635)
EUR 565

NF-kB p65 Polyclonal Antibody

MBS9140794-002mL 0.02mL
EUR 200

NF-kB p65 Polyclonal Antibody

MBS9140794-005mL 0.05mL
EUR 255

NF-kB p65 Polyclonal Antibody

MBS9140794-01mL 0.1mL
EUR 345

NF-kB p65 Polyclonal Antibody

MBS9140794-02mL 0.2mL
EUR 545

NF-kB p65 Polyclonal Antibody

MBS9140794-5x02mL 5x0.2mL
EUR 2265

Phospho-NF-kB p65 (S529)

MBS8533716-01mL 0.1mL
EUR 345

Phospho-NF-kB p65 (S529)

MBS8533716-01mLAF405L 0.1mL(AF405L)
EUR 565

Phospho-NF-kB p65 (S529)

MBS8533716-01mLAF405S 0.1mL(AF405S)
EUR 565

Phospho-NF-kB p65 (S529)

MBS8533716-01mLAF610 0.1mL(AF610)
EUR 565

Phospho-NF-kB p65 (S529)

MBS8533716-01mLAF635 0.1mL(AF635)
EUR 565

Anti-NF-kB p65 antibody

MBS175464-01mg 0.1mg
EUR 450

Anti-NF-kB p65 antibody

MBS175464-5x01mg 5x0.1mg
EUR 1870

Anti-NF-kB p65 antibody

MBS175572-01mg 0.1mg
EUR 450

Anti-NF-kB p65 antibody

MBS175572-5x01mg 5x0.1mg
EUR 1870

Anti-NF-kB p65 Antibody

MBS176854-01mg 0.1mg
EUR 450

Anti-NF-kB p65 Antibody

MBS176854-5x01mg 5x0.1mg
EUR 1870

Anti-NF-kB p65 Antibody

MBS178306-01mg 0.1mg
EUR 450

Anti-NF-kB p65 Antibody

MBS178306-5x01mg 5x0.1mg
EUR 1870

NF-kB p65 Polyclonal Antibody

MBS2566306-006mL 0.06mL
EUR 190

NF-kB p65 Polyclonal Antibody

MBS2566306-012mL 0.12mL
EUR 265

NF-kB p65 Polyclonal Antibody

MBS2566306-02mL 0.2mL
EUR 415

NF-kB p65 Polyclonal Antibody

MBS2566306-5x02mL 5x0.2mL
EUR 1835

NF-kB p65 Blocking Peptide

MBS9615152-1mg 1mg
EUR 380

NF-kB p65 Blocking Peptide

MBS9615152-5x1mg 5x1mg
EUR 1650

NF-kB p65 Blocking Peptide

MBS9620055-1mg 1mg
EUR 380

NF-kB p65 Blocking Peptide

MBS9620055-5x1mg 5x1mg
EUR 1650

NF-kB p65 Conjugated Antibody

MBS9456513-01mLAF350 0.1mL(AF350)
EUR 480

NF-kB p65 Conjugated Antibody

MBS9456513-01mLAF405 0.1mL(AF405)
EUR 480

NF-kB p65 Conjugated Antibody

MBS9456513-01mLAF488 0.1mL(AF488)
EUR 480

NF-kB p65 Conjugated Antibody

MBS9456513-01mLAF555 0.1mL(AF555)
EUR 480

Notably, ANKRD30B, a promising hub gene, was considerably hypermethylated in blood and downregulated in mind tissue from people with WS. Most CpG websites of ANKRD30B in blood have been considerably correlated with mind areas.

Furthermore, analyses of gene regulatory networks (GRNs) yielded grasp regulator transcription elements related to WS. Taken collectively, this systems-level method highlights the position of epigenetics in WS, and offers a doable rationalization for the advanced phenotypes noticed in sufferers with WS.

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